An Improved N-Acylation of 1 H-Benzotriazole Using 2,2′-DipyridylÂ-diÂ-sulfide and Triphenylphosphine

Abstract

A novel path has been developed for the conversion of carboxylic acids into the corresponding N-acylbenzotriazoles by using 2,2′-dipyridyl disulfide/PPh 3 in anhydrous dichloromethane in the presence of 1 H-benzotriazole. Mild reaction conditions, short reaction time, easy in handling, wide substrate scope, availability of reagents involved, and moreover avoiding the use of base makes this protocol quite useful for the laboratory practices for N-acylbenzotriazole synthesis. © Georg Thieme Verlag Stuttgar.