2019
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PublicationConference Paper Quadrature synchronization of two van der pol oscillators coupled by fractional-order derivatives(Springer Verlag, 2019) Aman K. Singh; R.D.S. YadavaThe paper presents a theoretical analysis of the synchronization behavior of two coupled Van der Pol oscillators, where the coupling is defined by fractional-order derivatives. The condition for frequency synchronization is obtained for the two oscillators being in-phase quadrature. It is found that the synchronization frequency oscillates rapidly with respect to the deviations from phase quadrature and the order of fractional derivative. The linear stability analysis is carried out by analyzing the roots of Jacobian on phase error. © 2019, Springer Nature Singapore Pte Ltd.PublicationArticle MEMS sensor array-based electronic nose for breath analysis - A simulation study(Institute of Physics Publishing, 2019) Anurag Gupta; T Sonamani Singh; R.D.S. YadavaThe paper presents a simulation study of breath analysis based on theoretical models of microelectromechanical structure (MEMS) cantilever sensor array. The purpose of this study is to suggest a methodology for the development of MEMS electronic nose (e-nose) for monitoring disease-specific volatiles in exhaled breath. Oxidative stress and diabetes are taken as case studies for the assessment of e-nose designs. The detection of ethane for general oxidative stress, isoprene for hypoxia, and acetone for diabetes are considered for targeted detection. A number of volatiles concurrently present in the exhaled breath are taken as interferents. The MEMS cantilevers are coated with volatile-selective polymers and are analyzed in both the static and dynamic modes. The sensor array is defined by polymer selections based on three data mining methods: principal component analysis (PCA), fuzzy c-means clustering (FCM), and fuzzy subtractive clustering (FSC). This utilizes vapor/polymer partition coefficients as a database. Analyses are carried out to find optimal combinations of the polymer selection method and cantilever sensing mode. Virtual breath analysis experiments are analyzed by PCA for target discrimination. It is found that no single combination works best in all conditions. The acetone (diabetes) detection is best in both sensing modes with the polymers selected by FSC; the isoprene (hypoxia) is detectable only in static sensing mode with polymers selected by FCM clustering; and the ethane (oxidative stress) detection is possible by all sensing modes and polymer selections, provided the breath samples are preconcentrated. This study suggests that it is difficult to realize a single general-purpose MEMS breath analyzer. The dedicated analyzers for specific disease indications can however be made with an optimal combination of sensing mode and polymer coatings. © 2018 IOP Publishing Ltd.PublicationConference Paper Heat equation-based ECG signal denoising in the presence of white, colored, and muscle artifact noises(Springer Verlag, 2019) Prateep Upadhyay; S.K. Upadhyay; K.K. ShuklaIn this paper, we have derived a novel solution of heat equation which comes out in the form of wavelet transformation and we have applied this solution to the signals of the MIT-BIH normal sinus rhythm database from PhysioBank in the presence of white Gaussian noise, colored noises, and muscle artifact (MA) noise respectively. It was found that the proposed method outperforms the recently reported method by Hamed Danandeh Hesar et al. in their specified SNR range of noises. © Springer Nature Singapore Pte Ltd. 2019.PublicationArticle On randers change of generalized mth root metric(Tusi Mathematical Research Group (TMRG), 2019) Manoj KumarIn the present paper, we find a condition under which a Finsler space with Randers change of generalized mth root metric is projectively related to an mth root metric. Then we find a condition under which Randers change of generalized mth root Finsler metric is locally projectively flat and also find a condition for locally dually flatness. © 2019 khayyam journal of mathematics.PublicationArticle Consensus on the management of posterior urethral valves from antenatal period to puberty(Wolters Kluwer Medknow Publications, 2019) Shilpa Sharma; Manoj Joshi; Devendra K. Gupta; Mohan Abraham; Praveen Mathur; J.K. Mahajan; A.N. Gangopadhyay; Simmi K. Rattan; Ravindra Vora; G. Raghavendra Prasad; N.C. Bhattacharya; Ram Samuj; K.L.N. Rao; A.K. BasuThe need for successful management of posterior urethral valves always captivates the minds of pediatric surgeons. Its success, however, depends on several factors ranging from prenatal preservation of upper tracts to postoperative pharmacological compliance. Regardless of measures available, some cases do not respond and progress to end stage. The management depends on several issues ranging from age and severity at presentation to long-term follow-up and prevention of secondary renal damage and managing valve bladder syndrome. This article is based on a consensus to the set of questionnaires, prepared by research section of Indian Association of Paediatric Surgeons and discussed by experienced pediatric surgeons based in different institutions in the country. Standard operating procedures for conducting a voiding cystourethrogram and cystoscopy were formulated. Age-wise contrast dosage was calculated for ready reference. Current evidence from literature was also reviewed and included to complete the topic. © 2018 Journal of Indian Association of Pediatric Surgeons | Published by Wolters Kluwer-Medknow.PublicationArticle A novel arp approach for cloud resource management(Blue Eyes Intelligence Engineering and Sciences Publication, 2019) Abhishek Kumar; K. Vengatesan; Rajiv Vincent; M. Rajesh; Achintya SinghalCloud computing proposes on-request arrange admittance to the calculating resources over virtualization. This changes in perspective the PC resources to the cloud giving price adequacy and it additionally gives versatile users openness to working resources. This proposal is execution prototypes of these frameworks with acceptance of entry of jobs to the framework and a work may comprise of numerous no.of jobs with every job needs a virtual machine for its implementation. This Paper consider both steady and variable task sizes in no.of jobs amid their administration times. On account of steady job estimate, this paperpermit distinctive classes of jobs, which are resolved over their entry and administration rates and no.of works in a job. In the multiple kind a job creates arbitrarily novel tasks amid its administration time. The last requires dynamic task of virtual machines to a work, which will be required in the versatile cloud. In the two cases, framework is displayed utilizing birth-demise forms. On account of consistent job measure, here decided joint likelihood dispersion of the quantity of works from every class in the framework, work delaying likelihoods and appropriation of the usage of resources for together heterogeneous and homogeneous kinds of virtual machines. Paper displayed mathematical results and any estimates are confirmed by usage result. © BEIESP.PublicationArticle Hindi adaptation of pediatric symptom checklist-youth version (PSC-Y)(Indian Association for Child and Adolescent Mental Health, 2019) Akanksha Chaurasiya; Jay Kumar Ranjan; Hari Shankar AsthanaBackground: The Pediatric Symptom Checklist-Youth Version (PSC-Y) is a widely used self-report measure designed to detect psychosocial dysfunctions in adolescents and youth. PSC-Y has been translated and validated in different languages. However, Hindi translation, as well as psychometric validation of PSC-Y, is yet to be done in India. Therefore, the objective of the present study was to translate the PSC-Y in Hindi language and psychometrically validate it in Indian setting. Method: To ascertain the psychometric properties; the Hindi version of PSC-Y, the Mental Health Inventory, the Adjustment Inventory, and the Hospital Anxiety and Depression Scale were administered to 300 secondary and higher secondary students of different schools of Varanasi and nearby places. Furthermore, after one month the Hindi translated version of PSC-Y was re-administered on 178 students. Results: Findings of the present study suggest that the Hindi version of PSC-Y has high test-retest reliability (r= 0.82, p< 0.01), and strong internal consistency (Cronbach α = 0.84, p < 0.01; Spearman-Brown r = 0.82, p< 0.01). The concurrent validity of the tool is also good, along with its sensitivity and specificity in detecting anxiety, depression and general mental health. Conclusion: The Hindi version of PSC-Y has good psychometric properties and further it can be used for the screening of the psychosocial dysfunctions among Indian adolescents. © 2019, Indian Association for Child and Adolescent Mental Health. All rights reserved.PublicationArticle A selective hydrolytic and restructuring approach through a Schiff base design on a coumarin platform for “turn-on” fluorogenic sensing of Zn 2+(Royal Society of Chemistry, 2019) Abha Pandey; Sharad Kumar Asthana; Anand Prakash; Jagat Kumar Roy; Ida Tiwari; K.K. UpadhyayA new Schiff base, CMD, designed based on a coumarin platform was synthesized and fully characterized through single crystal X-ray diffraction studies. CMD underwent selective Zn 2+ -triggered hydrolysis in ethanolic medium followed by restructuring of its fragments, resulting in a “turn-on” green fluorogenic response. This response was confirmed through various physico-chemical measurements along with single crystal X-ray diffraction studies. This selective hydrolytic fluorogenic event was exploited for the successful optical detection and live cell imaging of Zn 2+ in SiHa cells. The above restructured products were characterized as two new Schiff bases, viz.CM and NSA, of which NSA was highly fluorescent (green). Hence, the formation of this green fluorogenic product accounted for the above fluorogenic “turn-on” sensing of Zn 2+ with a sub-nanomolar detection limit. Spectroscopic evidence along with mass determinations indicated that the Zn-CMD ensemble took the form of CM-Zn-CM in solution, supporting our above proposal of hydrolysis and restructuring. However, the X-ray diffraction studies of the Zn-CMD ensemble further revealed it to consist of NSA and CM-Zn-CM′, where CM′ is yet another new Schiff base formed in situ during the process of developing single crystals. © The Royal Society of Chemistry.PublicationArticle Characterization of Allium germplasms for conservation and sustainable management using SSR markers(National Institute of Science Communication and Information Resources (NISCAIR), 2019) Kuldip Jayaswall; Abhishek Bhandawat; Himanshu Sharma; Vinod Kumar Yadav; Vijay Mahajan; Major SinghAllium species are very important due to their medicinal values. Quercetin and allicin are medicinally important compound of onion and garlic, respectively which are proved useful to treat various diseases. However, highly heterozygous nature, self-incompatibility and long gestation period limits genetic improvement of Allium species. Further, the existing germplasms in Indian subcontinents are largely cultivated ones with poor genetic characterization, which limits the germplasm conservation and future management. A total of thirty polymorphic Simple Sequence Repeats (SSRs) were utilized for characterisation of popular onion germplasms and their cross-transferability revealed relatedness with fifteen garlic and wild relatives. Average number of alleles per SSR locus, PIC and heterozygosity was found to be 3.9, 0.51 and 0.57,respectively.Overall genetic diversity recorded was higher in wild relative compared to cultivated A. cepa, possibly because most of the A. cepa variety is derived by domestication but wild relatives are open pollinated and undergoes extensive gene pool shuffling leading to higher heterogeneity. In this study, SSR markers were successfully utilized to assess genetic variations in popular Indian A. cepa, A. sativum and establish genetic relationships with wild Allium species. These markers can be harnessed for molecular breeding, varietal identification and planning germplasm conservation strategies in future. © 2019, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.PublicationArticle scribble (scrib) knockdown induces tumorigenesis by modulating Drp1-Parkin mediated mitochondrial dynamics in the wing imaginal tissues of Drosophila(Elsevier B.V., 2019) Amarish Kumar Yadav; Saripella Srikrishnascrib loss of function is associated with various human-cancers. Most of the human-cancers have been characterized by mitochondrial dysfunction with elevated oxidative stress. However, the role of scrib to mitochondrial dysfunction in cancer has not been investigated earlier. Here, we have shown that scrib knockdown leads to mitochondrial depolarization, fragmentation and perinuclear-clustering along with disruption of the redox homeostasis. Moreover, the scrib abrogated tumor showed the elevation of Drp-1 and reduced expression of Marf, which suggests enhanced mitochondrial-fission. Further, the reduced expression of Parkin and HtrA2 interpret defective mitophagy leading to clustering of fragmented mitochondria and apoptotic inhibition in scrib knockdown tumors. Also, Parkin immunostaining depicted its reduced expression and mislocalization in the tumor cells in comparison to wild type. Moreover, the genetic study revealed the epistatic interactions of parkin and scrib. Thus, for the first time our results suggested that scrib loss induced mitochondrial-dysfunction modulates cancer progression by altering the mitochondrial dynamics regulators. © 2018 Elsevier B.V. and Mitochondria Research Society
