2019

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Hypersensitivity pneumonitis and its correlation with ambient air pollution in urban India
(European Respiratory Society, 2019) Sheetu Singh; Bridget F. Collins; Mohan Bairwa; Jyotsna M. Joshi; Deepak Talwar; Nishtha Singh; Jai K. Samaria; Daya K. Mangal; Virendra Singh; Ganesh Raghu
[No abstract available]
Micro-scale variability impacts the outcome of competition between different modeled size classes of phytoplankton
(Frontiers Media S.A., 2019) Sandip Mandal; S. Lan Smith; Anupam Priyadarshi; Hidekatsu Yamazaki
Previous modeling studies have shown that observed micro-scale (mm) variability of nutrients and phytoplankton biomass can strongly impact the large-scale mean growth response of phytoplankton in ways that cannot be represented by typical models based on the mean field approximation. Also, models accounting for the flexible eco-physiology of phytoplankton predict quite different responses to changing environmental conditions compared to most current (inflexible) models. Combining these two ideas for nutrient-phytoplankton systems we have developed a new "Flexible NP closure model" to represent competition among the three typically observed phytoplankton size classes: pico-, nano-, and micro-phytoplankton. Both micro-scale variability and flexible eco-physiology are expected to impact the competition among these size classes. With this work we begin to address how both these factors determine the size structure and size diversity of phytoplankton in the ocean. Under eutrophic conditions, variability does not impact the modeled growth rate of any size class. On the other hand, under oligotrophic conditions, variability preferentially enhances the biomass of the largest typically observed micro-size class, and reduces the biomass of the smallest nano- and intermediate pico-size classes. © 2019 Mandal, Smith, Priyadarshi and Yamazaki.
Optimization of the bio-mechanical properties of Ti-8Si-2Mn alloy by 1393B3 bioactive glass reinforcement
(Institute of Physics Publishing, 2019) Vipul Saxena; Vijay Kumar; Amrendra Rai; Rishikesh Yadav; Uttam Gupta; Vinay Kumar Singh; Partha Pratim Manna
The low cost Ti-8Si-2Mn alloy matrix has been synthesized by powder metallurgical route. The alloy is reinforced with 1393 B3 bioactive glass to optimize the mechanical and biological properties. The reinforced weight percentage of glass is 0% (S1), 5% (S2), 10% (S3) and 20% (S4). The physical, mechanical, biological and corrosion properties of these composites were investigated. The cell culture suggests that composite S1 and S3 support the growth of the tumor cells when used at lower concentration. The hardness of samples decreases with the increasing percentage of reinforced glass; however, the respective hardness is still superior to the cortical bone. The composite S3 shows better compressive strength (339 MPa), low Young's modulus (76 GPa), optimum density (2.71 gm cm-3) and hardness (381 Hv) as compared to pre-existing Ti implants. So it can be proposed as a new novel load bearing bio implant which will potentially reduce the stress shielding effect, toxicity and will improve the Osseo conductivity. © 2019 IOP Publishing Ltd.
Recent trends in nanomaterials used in dairy industry
(Springer International Publishing, 2019) Amrita Poonia
The application of nanotechnology in the dairy industry is going to be a new revolution in the near future. The use of nanostructures in processing products of superior quality and safety and new packaging materials with improved desirable properties are being reported. The properties of bioactive compounds of dairy products can also be improved due to a reduction in the particle size. However, the safety issues about the ill effects of nanotechnology-based dairy foods on human health are of concern. So, there is a need to ensure the safety of nanofoods before commercial utilization. This chapter reviews the various topics like the use of many nano-based delivery systems in dairy products, milk proteins as the perfect natural carriers for nano-encapsulation purposes, nanostructures for the prevention of spoilage causing microorganisms and pathogens in dairy industry. Due to the health concerns, effects of intake of nanoparticles on digestive system, skin, brain, lungs and circulatory system have also been discussed. © Springer Nature Switzerland AG 2019.
Medicinal plants under climate change: Impacts on pharmaceutical properties of plants
(Elsevier, 2019) Akanksha Gupta; Prem Pratap Singh; Pardeep Singh; Kalpna Singh; Anand Vikram Singh; Sandeep Kumar Singh; Ajay Kumar
Climate change is one of the most severe threats to biodiversity as well as to ecosystem functioning. In this context, the influence of climate change also influences the important secondary metabolites of pharmaceutical plants. Elevated levels of CO2, ozone, drought, and cold conditions are major abiotic factors responsible for changing climatic conditions and factors that directly or indirectly influence the growth, production, and synthesis of plant secondary metabolites. The secondary metabolites of medicinal plants are currently used as a safe choice compared to the side effects and multidrug resistance conditions of allopathic treatment. Herbal plants and their products have been broadly used in the treatment of common diseases, like diabetes, cancer, cholera, diarrhea, asthma, pyrexia, since ancient times. Several plants and their secondary metabolites have been recognized to elicit beneficial effects on virulent factors of diseases in vivo and in vitro. Plants are extremely sensitive to climatic changes and do not acclimatize randomly. Some climatic factors enhance secondary metabolites, whereas other abiotic factors decrease the growth of plants to a certain extent. In the current chapter the effects of changing climatic conditions on medicinally important secondary metabolites of plants are summarized. © 2019 Elsevier Inc. All rights reserved.
Intelligent fuzzy rough set based feature selection using swarm algorithms with improved initialization
(IOS Press, 2019) Tarun Maini; Abhishek Kumar; Rakesh Kumar Misra; Devender Singh
This paper focuses on Fuzzy rough set, which is the fusion of fuzzy sets and rough sets theory for doing feature selection. For selecting the appropriate feature subset, swarm algorithms are used. The fitness function used here is Fuzzy Rough Dependency Measure. This paper demonstrates that by optimizing the fitness function, swarm algorithms are capable to select the best subset of features. Further, in this paper, an attempt has been made to improve the capability of the swarm based algorithms such as Intelligent Dynamic Swarm (IDS) and Particle Swarm Optimization (PSO) through modified initialization of solutions, for picking the appropriate features for the feature selection task. Improvement in the size of reducts and classification accuracy of these reducts are observed when initialization is done using the proposed method. Statistical t-tests have also been performed for the validation of the results. © 2019 - IOS Press and the authors. All rights reserved.
Recent advances in the development of coumarin derivatives as antifungal agents
(Springer Singapore, 2019) Rajesh Kumar Sharma; Diksha Katiyar
Coumarin is a privileged scaffold found in numerous pharmaceutically important natural products and synthetic molecules. The compounds bearing coumarin moiety exhibit broad spectrum of biological properties such as antibacterial, antiviral, anticancerous, anti-inflammatory, antihyperglycemic, and antipyretic activities. Coumarins are also well-known for their antifungal properties. In recent past, several literature reports have been published which highlight the importance of coumarin motif in the area of antifungal drug development. The present contribution provides an overview of synthetic and natural coumarins which have demonstrated potent antifungal activity, reported during 1992-2017. Structure Activity Relationship (SAR) may help medicinal chemists in the rational design and synthesis of new compounds based on coumarin scaffold for the treatment of fungal infections. © Springer Nature Singapore Pte Ltd. 2019.
Investigation of Inelastic Neutron Scattering on 27Al Nuclei
(Pleiades Publishing, 2019) N.A. Fedorov; T. Yu. Tretyakova; V.M. Bystritsky; Yu. N. Kopach; I.N. Ruskov; V.R. Skoy; D.N. Grozdanov; N.I. Zamyatin; W. Dongming; F.A. Aliev; K. Hramco; A. Kumar; A. Gandhi; S. Dabylova; D.I. Yurkov; Yu. N. Barmakov
The results obtained by measuring the angular and energy distributions of gamma rays produced in reactions induced by the inelastic scattering of 14.1-MeV neutrons on 27Al nuclei are presented. The respective measurements were performed by the tagged-neutron method in a beam from the ING-27 compact neutron generator. The angular distributions were obtained for gamma rays emitted from the 844-keV 1/2+, 1015-keV 3/2+, 2212-keV 7/2+, and 3004-keV 9/2+ states of 27 Al nuclei. © 2019, Pleiades Publishing, Ltd.
Aspect of ECMWF downscaled Regional Climate Modeling in simulating Indian summer monsoon rainfall and dependencies on lateral boundary conditions
(Springer-Verlag Wien, 2019) Soumik Ghosh; R. Bhatla; R.K. Mall; Prashant K. Srivastava; A.K. Sahai
Climate model faces considerable difficulties in simulating the rainfall characteristics of southwest summer monsoon. In this study, the dynamical downscaling of European Centre for Medium-Range Weather Forecast’s (ECMWF’s) ERA-Interim (EIN15) has been utilized for the simulation of Indian summer monsoon (ISM) through the Regional Climate Model version 4.3 (RegCM-4.3) over the South Asia Co-Ordinated Regional Climate Downscaling EXperiment (CORDEX) domain. The complexities of model simulation over a particular terrain are generally influenced by factors such as complex topography, coastal boundary, and lack of unbiased initial and lateral boundary conditions. In order to overcome some of these limitations, the RegCM-4.3 is employed for simulating the rainfall characteristics over the complex topographical conditions. For reliable rainfall simulation, implementations of numerous lower boundary conditions are forced in the RegCM-4.3 with specific horizontal grid resolution of 50 km over South Asia CORDEX domain. The analysis is considered for 30 years of climatological simulation of rainfall, outgoing longwave radiation (OLR), mean sea level pressure (MSLP), and wind with different vertical levels over the specified region. The dependency of model simulation with the forcing of EIN15 initial and lateral boundary conditions is used to understand the impact of simulated rainfall characteristics during different phases of summer monsoon. The results obtained from this study are used to evaluate the activity of initial conditions of zonal wind circulation speed, which causes an increase in the uncertainty of regional model output over the region under investigation. Further, the results showed that the EIN15 zonal wind circulation lacks sufficient speed over the specified region in a particular time, which was carried forward by the RegCM output and leads to a disrupted regional simulation in the climate model. © 2018, Springer-Verlag GmbH Austria, part of Springer Nature.
Maternal BDE-209 exposure during lactation causes testicular and epididymal toxicity through increased oxidative stress in peripubertal mice offspring
(Elsevier Ireland Ltd, 2019) Debarshi Sarkar; Deepanshu Joshi; Shio Kumar Singh
Decabromodiphenyl ether (BDE-209), a flame retardant, interferes with thyroid homeostasis and androgen biosynthesis. BDE-209 evokes hyperglycemia through impaired glucose homeostasis in rat liver. This study is in continuation to our earlier work for a better understanding of whether or not BDE-209 affects testicular and epididymal physiology in relation to oxidative status in peripupertal mice offspring. Lactating female Parkes mice were orally gavaged with 500 and 700 mg/kg body weight of BDE-209 in corn oil from postnatal day (PND)1 to PND 28. Male pups of lactating dams were sacrificed at PND 42. Maternal BDE-209 exposure during lactation increased apoptosis and oxidative status with altered expressions of various cell survival (Bcl-2), apoptotic (Bax and caspase-3)and oxidative stress (Nrf2 and HO-1)markers in testes and epididymis of peripubertal mice offspring. Testicular glucose and lactate concentrations were markedly reduced in these pups with down-regulation in GLUT3 and GLUT8 expressions and decreased LDH activity. Maternal BDE-209 exposure markedly affected fertility potential, epididymal histology, sialic acid concentration and sperm quality with decreased expression of epididymal Cx43 and AR in these mice offspring. Results thus suggest that maternal BDE-209 exposure during lactation causes reproductive toxicity in peripubertal mice offspring. © 2019 Elsevier B.V.
Presence of adult Loa loa in the anterior chamber of the eye along with microfilaremia from nonendemic region: A rare presentation from India
(Wolters Kluwer Medknow Publications, 2019) Varsha Kumari; Sofia Ahmad; Aradhana Singh; Tuhina Banerjee
We report an unusual case of adult Loa loa infection in the anterior chamber of the eye of a 65-year-old female from rural area of Jharkhand, India, with no history of travel to endemic places but the presence of microfilaria of Loa loa in blood. Loiasis is endemic to African countries, with few sporadic cases affecting the Indian population. However, in none of the reports, microfilaremia was detected. This atypical feature in this case adds to the epidemiological variations in parasitic presentations in nonendemic regions. © 2019 Tzu Chi Medical Journal.
Scanning electron microscopic finding of heart in a case of celphos poisoning
(Punjab Academy of Forensic Medicine and Toxicology, 2019) Manoj Kumar Pathak; Rohini
[No abstract available]
Re-addressing the biosafety issues of plant growth promoting rhizobacteria
(Elsevier B.V., 2019) Chetan Keswani; Om Prakash; Nidhi Bharti; Juan I. Vílchez; Estibaliz Sansinenea; Richard D. Lally; Rainer Borriss; Surya P. Singh; Vijai K. Gupta; Leonardo F. Fraceto; Renata de Lima; Harikesh B. Singh
To promote agronomic sustainability, extensive research is being carried out globally, investigating biofertilizer development. Recently, it has been realized that some microorganisms used as biofertilizers behave as opportunistic pathogens and belong to the biosafety level 2 (BSL-2) classification. This poses serious risk to the environmental and human health. Evidence presented in various scientific forums is increasingly favoring the merits of using BSL-2 microorganisms as biofertilizers. In this review, we emphasize that partial characterization based on traditional microbiological approaches and small subunit rRNA gene sequences/conserved regions are insufficient for the characterization of biofertilizer strains. It is advised herein, that research and industrial laboratories developing biofertilizers for commercialization or environmental release must characterize microorganisms of interest using a multilateral polyphasic approach of microbial systematics. This will determine their risk group and biosafety characteristics before proceeding with formulation development and environmental application. It has also been suggested that microorganisms belonging to risk-group-1 and BSL-1 category should be used for formulation development and for field scale applications. While, BSL-2 microorganisms should be restricted for research using containment practices compliant with strict regulations. © 2019 Elsevier B.V.
ZrB2 nanoparticles transmuting tribological properties of Al3Zr/AA5052 composite
(Springer Verlag, 2019) Gaurav Gautam; Narendra Kumar; Anita Mohan; Sunil Mohan; Devendra Singh
Good work hardenability, moderate to high strength of AA5052 alloy and high melting point and elastic modulus of Al3Zr with limited wear resistance have been the driving force to transmute Al3Zr/AA5052 composite by generations of ZrB2 nanoparticles. For this purpose, the varying amounts of ZrB2 particles in Al3Zr/AA5052 composite have been produced by direct melt reaction in situ technique. The phase identification, microstructural studies and wear testing have been performed for all the composites. The phase identification and microstructural studies indicate that the ZrB2 particles are formed successfully in the Al3Zr/AA5052Al composite with hexagonal and rectangular morphology within a size range of 10–190 nm. Wear testing results show that friction coefficient (COF) fluctuates with sliding distance, whereas it decreases with normal load. For the composite without ZrB2, the COF is exhibited increasing trend with sliding velocity, while for the hybrid composites initially it decreases, but beyond 2 m/s sliding velocities it starts increasing. Wear studies also show that with ZrB2 generation in Al3Zr/AA5052 composites can be used up to larger loads and higher sliding velocities while being in mild wear regime. It is observed that the mild wear regime extends and COF increases with the increase in vol% of ZrB2 particles. Texture analysis of worn surfaces is in agreement with the results. The present investigation shows that in situ (ZrB2 + Al3Zr)/AA5052 hybrid composites could be a promising material in the applications requiring high wear resistance and high COF such as braking system. © 2019, The Brazilian Society of Mechanical Sciences and Engineering.
Nanocatalyst types and their potential impacts in agroecosystems: An overview
(Elsevier, 2019) Rahul Bhadouria; Disha Mishra; Vipin Kumar Singh; Pardeep Singh; Pratap Srivastava; Sachchidanand Tripathi; Rishikesh Singh
Agricultural intensification by the increased inputs of agrochemicals has resulted in several negative environmental consequences. Currently the precise use of agrochemicals is being recommended to improve crop yield and environmental health. Application of various precision agricultural practices is being promoted to attain the agricultural sustainability. Nanotechnology as a modern tool has been considered as a potential tool for the precise application of agrochemicals and efficient utilization by the crop plants in the agroecosystems. In this context, the application of spent nanocatalysts in the agroecosystems has been increased considerably for the management of these spent catalysts. Numbers of studies have shown significant impact of spent nanocatalysts on plant germination and growth behaviors. In this chapter a brief insight has been given on the development and application of novel nanomaterials (NMs) in agriculture and environment along with their fate and behavior. Further, recent developments in plant science regarding nanobiotechnology that focuses on agricultural practices, plant growth, and yield are also emphasized. Moreover an effort has been made to collate the studies dealing with the utilization of spent nanocatalysts and nanomaterials used in various value-added products in the agricultural systems. © 2020 Elsevier Inc. All rights reserved.
5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology
(Academic Press Inc., 2019) Aruna Sharma; Rudy J. Castellani; Mark A. Smith; Dafin Fior Muresanu; Prasanta Kumar Dey; Hari Shanker Sharma
5-Hydroxytryptophan (5-HTP), a precursor of serotonin, is therapeutically used for several psychiatric disorders such as anxiety and depression in the clinic. However, severe side effects, including abnormal mental functions, behavioral disturbances and intolerance are associated with this treatment. 5-HTP-induced elevation of plasma and brain serotonin levels may affect blood-brain barrier (BBB) breakdown, edema formation and regional cerebral blood flow (CBF) disturbances. Breakdown of BBB to serum proteins leads to vasogenic brain edema formation and cellular injuries. However, 5-HTP-neurotoxicity is still not well known. In this investigations 5-HTP induced elevation of endogenous plasma and brain serotonin levels and its effect on BBB breakdown, edema formation neuronal injuries was examined in a rat model. Furthermore, potential role of oxidative stress and nitric oxide (NO) was evaluated. In addition, several neurochemical agents such as p-CPA (5-HT synthesis inhibitor) indomethacin (prostaglandin synthase inhibitor), diazepam (ant stress drug), cyproheptadine, ketanserin (5-HT2 receptor antagonists) and vinblastine (inhibitor of microtubule function) were examined on 5-HT neurotoxicity. Our observations suggest that 4 h after 5-HTP administrations, the endogenous serotonin levels increased by fourfold (150 mg/kg) in the plasma and brain associated with profound hyperthermia (+ 3.86 ± 0.24 °C, oxidative stress and NO upregulation. Breakdown of the BBB to Evans blue albumin (EBA) in 8 brain regions and to [131]Iodine in 14 brain regions was observed. The CBF exhibited marked reduction in all the brain regions examined. Brain edema and cellular injuries are present in the areas associated with BBB disruption. Drug treatments reduced the BBB breakdown, edema formation NO production and brain pathology. These observations are the first to point out that 5-HTP-neurotoxicity caused by BBB breakdown, edema formation and NO production is instrumental in causing adverse mental and behavioral abnormalities, not reported earlier. © 2019 Elsevier Inc.
Sol-gel synthesis, crystalline phase, optical absorption, and photo-luminescence behavior of cerium-doped (Ba0.5Sr0.5)FeO3-δ powders
(Institute of Physics Publishing, 2019) Santosh Chauhan; L.K. Pradhan; M. Kar; R.K. Singh; Jitendra Kumar; Shivendra Kumar Jaiswal
The cerium- and iron-based perovskite type materials have received attention due to their applications in solid oxide fuel cells, sensors, catalysts, and gas separation membranes. An attempt has been made here to synthesize (Ba0.5Sr0.5)(Fe1-xCex)O3-δ (x = 0-1.0) compounds and characterize them for crystalline phases, photoluminescence and optical absorption properties. They are shown to exhibit phases as perovskite-type cubic for x = 0, cubic as well as orthorhombic in the composition range 0.1 ≤ x ≤ 0.6 and orthorhombic alone for 0.8 ≤ x ≤ 1.0. The lattice parameter of cubic phase increases with cerium content, value being ∼3.937 Å and 3.981 Å for x = 0 and 0.60, respectively with Z = 1 and space group Pm3m. The orthorhombic cell has ao = 8.871 Å, bo = 6.392 Å, co = 5.991 Å, Z = 4 and space group Pnma for the composition x = 1.0. Cerium insertion leads to lattice expansion, weakening of metal-oxygen bonds, creation of oxygen vacancies, M4+ → M3+ (M = Ce and/or Fe) conversion, and creation of defect levels within the band gap. Their photoluminescence spectra provide evidence for structural defects including oxygen vacancies. The optical absorption peaks at 620 and 700 nm are attributed to various charge transfer transitions. The characteristics make the (Ba0.5Sr0.5)(Fe1-xCex)O3-δ system technological viable for oxygen separation from air. © 2019 IOP Publishing Ltd.
Dicarboxylate transporters of Azospirillum brasilense Sp7 play an important role in the colonization of finger millet (Eleusine coracana) roots
(American Phytopathological Society, 2019) Vijay Shankar Singh; Prajna Tripathi; Parul Pandey; Durgesh Narain Singh; Basant Kumar Dubey; Chhaya Singh; Surendra Pratap Singh; Rachana Pandey; Anil Kumar Tripathi
Azospirillum brasilense is a plant growth-promoting bacterium that colonizes the roots of a large number of plants, including C3 and C4 grasses. Malate has been used as a preferred source of carbon for the enrichment and isolation Azospirillum spp., but the genes involved in their transport and utilization are not yet characterized. In this study, we investigated the role of the two types of dicarboxylate transporters (DctP and DctA) of A. brasilense in their ability to colonize and promote growth of the roots of a C4 grass. We found that DctP protein was distinctly upregulated in A. brasilense grown with malate as sole carbon source. Inactivation of dctP in A. brasilense led to a drastic reduction in its ability to grow on dicarboxylates and form cell aggregates. Inactivation of dctA, however, showed a marginal reduction in growth and flocculation. The growth and nitrogen fixation of a dctP and dctA double mutant of A. brasilense were severely compromised. We have shown here that DctPQM and DctA transporters play a major and a minor role in the transport of C4-dicarboxylates in A. brasilense, respectively. Studies on inoculation of the seedlings of a C4 grass, Eleusine corcana, with A. brasilense and its dicarboxylate transport mutants revealed that dicarboxylate transporters are required by A. brasilense for an efficient colonization of plant roots and their growth. © 2019 The American Phytopathological Society.
Experimental evidence of molecular coherence effects in the bremsstrahlung radiation processes
(Institute of Physics Publishing, 2019) Suman Prajapati; Bhupendra Singh; Sunil Kumar; B.K. Singh; R. Shanker
The first experimental evidence of Young-type interferences is presented in bremsstrahlung (BS) processes by measuring the double differential cross sections (DDCS) of BS photons emitted from a two-centre N2 molecule under impact of 4.0 keV electrons. The spectra were recorded for emission of photons in the angular range of 45°-120° and the energy range of 2.0-3.8 keV using a Si PIN photodiode detector (FWHM = 165 eV at 5.9 keV). The measured variation of DDCS ratio of N2 to Ar as a function of photon energy shows no obvious signature of interference structure. However, the measured angular distribution of the intensity ratio of BS photons of N2 to Ar is found to exhibit the noticeable oscillations. Furthermore, a clear oscillatory structure is observed in the angular distribution of BS photons if the intensity of photons emitted from N2 molecules at angle θ to the intensity of photons emitted at angle 90°, i.e. I(θ)/I(90°) is plotted as a function of emission angle. Noting the fact that, only one theoretical work on coherence effects in BS processes under low-energy electron impact with homonuclear diatomic molecules is reported in the literature by Borie et al (1970 Phys. Rev. A 2 1443) which fails to explain the observed oscillations and shows orders of magnitude difference in the amplitude and mismatch in the shape of oscillations. The presence of observed oscillations is suggested to arise due to coherent superposition of BS photons of a given energy emitted in scattering of 4.0 keV electrons with a two-centre N2 molecule. Strong disagreement between our measurements and the calculations from Borie et al theory clearly suggests that a more refined and adequate theoretical model together with additional experimental investigations are needed to verify the present observations. © 2019 IOP Publishing Ltd.
Modeling of 2011 IndoNepal Earthquake and Scenario Earthquakes in the Kumaon Region and Comparative Attenuation Study Using PGA Distribution with the Garhwal Region
(Birkhauser Verlag AG, 2019) Sandeep; A. Joshi; S.K. Sah; Parveen Kumar; Sohan Lal; Sonia Devi; Monika
Kumaon and Garhwal regions are the chief terrains of Uttarakhand Himalaya. The present article simulates the strong ground motion of the 2011 IndoNepal earthquake in the Kumaon region using modified semi empirical technique (MSET). Acceleration records at ten stations in the near field region have been simulated which validates well with actual records and therefore confirms the reliability of MSET. In addition, MSET has been used to simulate strong motion records of future scenario earthquakes (Mw 7.0 and Mw 8.0) in Kumaon region by assuming the earthquake location same as that of 2011 IndoNepal earthquake. Isoacceleration maps are also provided, which reveals more than 400 gal value of PGA at epicentral distances less than 25 kms for an earthquake of magnitude 8.0. The comparison of isoacceleration map of future scenario earthquake (Mw 7.0) in Kumaon region has been done with isoacceleration map of 1991 Uttarkashi earthquake (Mw 6.8) in Garhwal region which suggests distinct attenuation characteristics of these two regions. © 2019, Springer Nature Switzerland AG.