Structural and functional analysis of protein

Abstract

This chapter deals with the topic of bioinformatics approaches applied to biology, essentially for the analysis and characterization of protein. Protein is a large and diverse class of biomolecules, involved in various functional and structural parts in all forms of life. Advances in the experimental techniques and computational methodology have facilitated a relevant understanding of the 3D arrangement of the protein structures and the molecular level insight of the protein function. The collective exponential growth of the solved 3D structures has been utilized extensively to develop an advanced computational program to classify the structure information in different hierarchical levels, to develop more accurate machine learning-based protocols for 3D-structure prediction and scoring function, and to understand the mysterious protein folding problem. This chapter discusses the state-of-the-art computational techniques oriented toward the protein structure and function prediction from the sequence. These methods, if used appropriately, can provide valuable indicators of protein structure and prediction. © 2022 Elsevier Inc. All rights reserved.