Glycohybrid molecules in medicinal chemistry: Present status and future prospective

Abstract

Hybrid molecules combine two distinct biologically relevant molecules that act at different biological targets with new mechanism are becoming molecules for interest among medicinal chemist and biological chemists. Hybrid molecules are usually defined as a molecular framework in which a linker, often a stable hydrocarbon chain, heterocyclic ring connects the two biologically relevant molecules with altered bioactivity profile. Carbohydrates play important roles in the natural world as diverse as energy storage, molecular recognition for intracellular trafficking or interactions between pathogenic bacteria and viruses and the surfaces of vertebrate’s cells. The carbohydrates present inside and at the surface of cells mediate many biological processes that are fundamentally important for human health. In the current chapter we have covered the medicinal chemistry aspects of recently reported glycohybrid molecules with respect to their anticancer, antiviral, antibacterial, antifungal, immununomodulatory, PTP1B inhibitors, carbonic anhydrase inhibitors, antimalarial, glycosidase inhibitors, galectin-3-inhibitors and anti-inflammatory activity. © 2020 Elsevier Inc. All rights reserved.