Correction to: Polyamine-Associated changes in circadian gene expression and their relationship to GnRH-I expression (Endocrine, (2025), 90, 3, (1446-1458), 10.1007/s12020-025-04444-z)

Abstract

In the abstract section of this article, in the method and result section, the sentence “A prospective cohort of 56 end stage kidney disease patients on maintenance HD treatment (mean age 65.3 ± 13.1, females 80%) was qPCR analysis revealed a marked elevation in circadian gene mRNA levels in the adult hypothalamus, but these levels decreased significantly with aging” have been included inadvertently. The old and incorrect version of “Method and Result” section of abstract are given below. Incorrect version: Method and Result A prospective cohort of 56 end stage kidney disease patients on maintenance HD treatment (mean age 65.3 ± 13.1, females 80%) was qPCR analysis revealed a marked elevation in circadian gene mRNA levels in the adult hypothalamus, but these levels decreased significantly with aging. RNA sequencing analysis of GT1-7 cells treated with Putrescine revealed significant upregulation in pathways associated with GnRH secretion, GnRH signaling, and circadian entrainment. Using hypothalamic GT1-7 cells treated with Putrescine, we observed a concurrent upregulation of GnRH and core circadian genes in a Temporal manner, with significant changes observed at 6-hour intervals. Correlation analysis further demonstrated that the mRNA expression of circadian genes was strongly and positively correlated with GnRH mRNA levels under Putrescine treatment. Additionally, in an in vivo study the disruption of circadian rhythmicity in the hypothalamus was shown to abolish the inherent rhythmicity of both polyamines and GnRH expression, further highlighting the interplay between these systems Corrected version: Method and Result qPCR analysis revealed a marked elevation in circadian gene mRNA levels in the adult hypothalamus, but these levels decreased significantly with aging. RNA sequencing analysis of GT1-7 cells treated with putrescine revealed significant upregulation in pathways associated with GnRH secretion, GnRH signaling, and circadian entrainment. Using hypothalamic GT1-7 cells treated with putrescine, we observed a concurrent upregulation of GnRH and core circadian genes in a temporal manner, with significant changes observed at 6-hour intervals. Additionally, in an in vivo study the disruption of circadian rhythmicity in the hypothalamus was shown to abolish the inherent rhythmicity of both polyamines and GnRH expression, further highlighting the interplay between these systems. The original article has been corrected. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.