2003

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Browsing 2003 by Author "Abhilasha"

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    Seasonal adiposity and delayed ovulation in a vespertilionid bat, Scotophilus heathi: Role of tumor necrosis factor-α
    (2003) Chanda, Diptiman; Abhilasha; Krishna, Amitabh
    The aim of this article was to evaluate the physiological significance of tumor necrosis factor-α (TNF-α) in seasonal accumulation of adipose tissue, hyperinsulinemia, and anovulation in Scotophilus heathi. The result showed seasonal variations in the circulating TNF-α level. A higher level of circulating TNF-α was observed during quiescence and recrudescence, whereas a lower level of TNF-α was observed during winter dormancy and the preovulatory period. An increased circulating TNF-α level coincided closely with accumulation of adipose tissue and hyperinsulinemia. Immunocytochemical localization of TNF-α in the ovary showed immunoreactivity mainly in the oocytes and theca-interstitial cells. The oocytes of small and medium-sized follicles showed strong TNF-α immunostaining, whereas weak immunoreactivity was observed in the large antral follicles. The atretic follicles showed mild TNF-α immunostaining. TNF-α immunoreactivity in the ovary was slightly higher during the quiescence and preovulatory periods compared with the periods of recrudescence and winter dormancy. TNF-α alone significantly increased androstenedione and estradiol production by the ovary in vitro but did not augment the luteinizing hormone (LH)-induced androstenedione production. However, TNF-α did augment LH-induced estradiol production. The results of this study suggest the involvement of TNF-α in the interaction among adipose tissue accumulation, insulin resistance, and ovarian activity in S. heathi.