2003

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Browsing 2003 by Author "Acharya, S.B."

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    A preliminary study on the effect of Azadirachta indica on bronchial smooth muscles and mast cells
    (Natural Remedies Private Limited, 2003) Acharya, S.B.; Yanpallewar, S.U.; Singh, R.K.
    Objective: The present study was designed to assess the protective effect of Azadirachta indica on bronchial smooth muscles and mast cells. Methods: Azadirachta indica (200 mg/kg p.o.) leaf juice was administered to animals and its protective effect was determined on histamine aerosol induced bronchospasm in guinea pigs, comp 48/80 induced mast cell degranulation and active anaphylaxis in rats. Results: A significant protection against histamine induced bronchospasm in guinea pigs was observed. There was 63% delay in onset of dyspnoea in A. indica treated animals against that of 16% in control animals. A. indica neither could prevent mast cell degranulation nor could protect against active anaphylaxis. Conclusion: The results of the present preliminary study reveal that A. indica has bronchoprotective role. Moreover, it also suggests that mechanisms other than that associated with mast cell degranulation or active anaphylaxis are possibly involved in bronchoprotective role of A.indica.
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    Effect of Azadirachta indica on paracetamol-induced hepatic damage in albino rats
    (Urban und Fischer Verlag Jena, 2003) Yanpallewar, S.U.; Sen, S.; Tapas, S.; Kumar, Mohan; Raju, S.S.; Acharya, S.B.
    Azadirachta indica, a plant used widely in Ayurveda, has been reported to have anti-inflammatory, immunomodulatory and adaptogenic properties. The present study evaluates its hepatoprotective role. Fresh juice of tender leaves of Azadirachta indica (200 mg/kg body wt. p.o.) inhibited paracetamol (2 g/kg body wt. p.o.)-induced lipid peroxidation and prevented depletion of sulfhydryl groups in liver cells. There was an increase in serum marker enzymes of hepatic damage (aspartate transaminase, alanine transaminase and alkaline phosphatase) after paracetamol administration. Azadirachta indica pretreatment stabilized the serum levels of these enzymes. Histopathological observations of liver tissues corroborated these findings.