Browsing by Author "Chaubey T.N."

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    Annulative coupling of sulfoxonium ylides with 2-amino(thio)phenols: easy access to 2-acyl benzox(thio)azoles
    (Royal Society of Chemistry, 2024) Chaubey T.N.; Borpatra P.J.; Pandey S.K.
    A novel method for synthesizing 2-acyl benzothiazoles and benzoxazole derivatives has been developed via the annulative coupling of sulfoxonium ylides with 2-aminobenzenethiol and 2-aminophenol derivatives, respectively. This metal-free, one-pot protocol employs elemental sulfur as a mediator to efficiently construct C-N, C-S, or C-O bonds and demonstrates a broad range of functional group compatibility. The potential utility of this approach is further demonstrated through large-scale reactions and the synthesis of some bioactive compounds. � 2024 The Royal Society of Chemistry.
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    Elemental Sulfur-Promoted Annulative Coupling of 2-Aminobenzamides and 2-Aminobenzylamines with Sulfoxonium Ylides: Access to Quinazolinones and Quinazolines
    (John Wiley and Sons Inc, 2024) Chaubey T.N.; Borpatra P.J.; Pandey S.K.
    A novel and straightforward approach for synthesizing quinazolinones and quinazoline derivatives employing sulfur-mediated annulative coupling of 2-aminobenzamides and 2-aminobenzylamines in conjunction with sulfoxonium ylides has been described. This method demonstrates a broad substrate range and exhibits excellent tolerance towards various functional groups. Finally, this protocol has been successfully applied to synthesize pyrazino-fused quinazolinone derivative with adjustable fluorescence properties and tryptanthrin, a compound known for its potent antitubercular activity. � 2024 Wiley-VCH GmbH.
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    I2-Mediated Site-Selective C-H Functionalization: Access to p-Amino-Substituted Unsymmetrical Benzils and Quinoxalines from Sulfoxonium Ylides
    (American Chemical Society, 2024) Saini R.K.; Borpatra P.J.; Chaubey T.N.; Pandey S.K.
    An I2-mediated approach for selective C-H functionalization of unprotected aniline derivatives for synthesizing benzils and quinoxaline derivatives from sulfoxonium ylides has been described. Aniline derivatives and sulfoxonium ylides ornamented with different functional groups showed good compatibility. They afforded the corresponding products with moderate to high yields via a mild and simple procedure. Finally, we validated the practicality of this method by scaling up the reaction and further conversion of the synthesized derivatives into other valuable molecules. � 2024 American Chemical Society.
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    Multicomponent Tandem Cyclization/Aromatization Reaction: Access to 2-Substituted Naphthothiazoles and Benzothiazoles
    (John Wiley and Sons Inc, 2024) Kumar U.; Sharma A.; Chaubey T.N.; Pandey S.K.
    A straightforward, metal-free multicomponent tandem cyclization/aromatization approach for the synthesis of naphthothiazoles and benzothiazoles is described. This method employs ?-tetralones and cyclohexenones as the starting materials, styrene derivatives as a one-carbon synthon, an ammonium salt as the N source, elemental sulfur as the S source and an oxidant. This approach offers a broad substrate scope, including ?-tetralones and cyclohexenones adorned with different functional groups, resulting in moderate to high yields of the desired products. � 2024 Wiley-VCH GmbH.