Browsing by Author "Gupta, Supriya"

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    A rare incidence and management of complex odontoma and surgical dehiscence in maxillary anterior region: A case report
    (Wolters Kluwer Medknow Publications, 2023) Gupta, Sakshi; Mittal, Neelam; Shankari, Thivya; Gupta, Supriya
    Odontoma is a benign odontogenic tumour, which is rather considered hamartoma. Hamartoma is not a true neoplasm, rather a growth of abnormal mixture of cells found in the body area they normally grows. Fully developed odontomas generally consist of enamel, dentin and pulpal tissues, in an unorganised manner. Some of them may contain cementum too. These are further grouped into compound and complex, depending on their clinical, radiographic and histologic features. Odontomas are generally asymptomatic and slow growing, but may cause bone expansion and hinderance in tooth eruption. These lesions are generally diagnosed by coincidence in radiograph. We are presenting a case and surgical management of complex odontoma and post?operative dehiscence in the anterior right maxillary region of a 38?year?old male. � 2023 National Journal of Maxillofacial Surgery.
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    Comparative analysis of reduction in pain scores after single visit root canal treatment using endodontic irrigation protocols, namely, Conventional needle irrigation, PUI, PIPS and SWEEPS: A randomized control trial
    (Wolters Kluwer Medknow Publications, 2023) Mittal, Neelam; Baranwal, Harakh Chand; Gupta, Sakshi; Shankari, Thivya; Gupta, Supriya; Kharat, Shubham
    Introduction: To assess the effects of different irrigation activation systems on postoperative pain using a Visual Analog Scale (VAS), using new laser irrigation activation system shock wave-enhanced emission photoacoustic streaming (SWEEPS), photon-induced photoacoustic streaming (PIPS), passive ultrasonic irrigation activation techniques, compared with the conventional irrigation (CI) method. Materials and Methods: Sixty patients suffering from symptomatic irreversible pulpitis in maxillary or mandibular molars were enrolled and randomly assigned to four different irrigation activation groups (n = 15) after chemomechanical root canal preparation. Preoperative and postoperative pain scores were recorded using VAS. The data were collected and subjected to statistical analysis using IBM SPSS 20.0 software at a level of significance being 0.05. Results: We observed that mean pain scores decreased with time in all patients in all groups. The decrease in pain score was found to be statistically significant (P < 0.05) among both the genders in Group 3 (PIPS) and Group 4 (SWEEPS). Postoperatively, pain scores decreased significantly using Group 4 (SWEEPS), followed by Group 3 (PIPS), Group 2 (ultrasonic activation), and Group 1 (conventional needle irrigation). No significant relation was observed statistically between pain scores and age groups among all groups, except for preoperative score in Group 3 and age groups. Conclusion: Postoperative scores were lower in laser-activated irrigation systems as compared to the other activation systems. The highest pain scores were observed in case of CI method, at pre- and post-operative periods. � 2023 Journal of Conservative Dentistry | Published by Wolters Kluwer - Medknow .
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    Comparative evaluation of bioglass nanofiber, dexamethasone-coated bioglass nanofiber, and platelet-rich fibrin, as scaffolds in regenerative endodontic treatment of immature necrotic teeth: A randomized controlled trial
    (Wolters Kluwer Medknow Publications, 2022) Gupta, Sakshi; Mittal, Neelam; Baranwal, Harakh Chand; Rath, Chandana; Shankari, Thivya; Gupta, Supriya
    Aim: The aim of this study was to evaluate and compare the regenerative endodontic potential of dexamethasone-coated bioglass nanofiber (Dex-BGnf), bioglass nanofiber (BGnf), and platelet-rich fibrin (PRF) for inducing regeneration in necrotic immature permanent teeth. Materials and Methods: A total of 36 (n = 12) immature necrotic teeth with or without evidence of periapical lesion were included in the study. Patients were randomly allocated into three groups, based on the scaffolds used: Group I (PRF), II (BGnf), and III (Dex-BGnf). The clinical (electric pulp test) and radiographic evaluations (percentage increase in apical diameter, root length, root dentin thickness, and periapical healing) were compared at 6 and 12 months after the procedure with baseline records. Statistical Analysis: One-way ANOVA, post hoc Tukey analysis, and Kruskal-Wallis test were used for evaluating the data. A 6- and 12-month improvement analysis was done using paired t-test and Friedman test. Results: Clinically, all the 36 teeth were asymptomatic, but none gave a positive response to Electric Pulp Test (EPT) in time interval of 12 months. Dex-BGnf showed a statistically significant improvement in terms of increase in root length (P = 0.020) and root dentinal thickness (P = 0.001) when compared to PRF after 12 months. Conclusion: The study has shown that Dex-BGnf yielded significantly better results than PRF for inducing apexogenesis in necrotic immature teeth. � 2022 Wolters Kluwer Medknow Publications. All rights reserved.
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    Genome mining of Fusarium reveals structural and functional diversity of pectin lyases: a bioinformatics approach
    (Springer Science and Business Media Deutschland GmbH, 2022) Yadav, Kanchan; Dwivedi, Shruti; Gupta, Supriya; Dubey, Amit K.; Singh, Vinay K.; Tanveer, Aiman; Yadav, Sangeeta; Yadav, Dinesh
    Pectin lyase (PNL) is an important enzyme of the pectinases group which degrades pectin polymer to 4,5-unsaturated oligogalacturonides by a unique ?-elimination mechanism and is used in several industries. The existence of multigene families of pectin lyases has been investigated by mining microbial genomes. In the present study, 52 pectin lyase genes were predicted from sequenced six species of Fusarium, namely F. fujikuroi, F. graminearum, F. proliferatum, F. oxysporum, F. verticillioides and F. virguliforme. These sequences were in silico characterized for several physico-chemical, structural and functional attributes. The translated PNL proteins showed variability with 344�1142 amino acid residues, 35.44�127.41�kDa molecular weight, and pI ranging from 4.63 to 9.28. The aliphatic index ranged from 75.33 to 84.75. Multiple sequence alignment analysis showed several conserved amino acid residues and five distinct groups marked as I, II, III, IV, and V were observed in the phylogenetic tree. The Three-dimensional Structure of five of these PNLs, each representing a distinct group of phylogenetic trees was predicted using I-TASSER Server and validated. The pectin lyase proteins of Fusarium species revealed close similarity with pectin lyase of Aspergillus niger PelA(1IDJ) and PelB(1QCX). Diversity in the structural motifs was observed among Fusarium species with 2 ?-sheets, 1 ?-hairpin, 7�12 ? bulges, 18�25 strands, 6 -11 helices, 1 helix-helix interaction, 32�49 ? turns, 2�6 ? turns and 2- 3 disulfide bonds. The unique Pec_lyase domain was uniformly observed among all PNL proteins confirming its identity. The genome-wide mining of Fusarium species was attempted to provide the diversity of PNL genes, which could be explored for diverse applications after performing cloning and expression studies. � 2022, King Abdulaziz City for Science and Technology.
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    Management of Cracked Maxillary First Molar with Erbium?Doped Yttrium Aluminum Garnet Laser
    (Wolters Kluwer Medknow Publications, 2022) Mittal, Neelam; Gupta, Supriya; Gupta, Sakshi; Shankari, Thivya
    Treatment and diagnosis of fractured teeth present a big challenge to dentists. Treatment of traumatized teeth can be done with reattachment of a dental fragment both in simple and complicated coronal fractures. A 28-year-old male patient came to our department with a traumatic crown fracture of the permanent, left maxillary molar. The patient complained of pain upon mastication, and on examination left maxillary second molar has a fracture line extending in a mesiodistal direction. Partial pulpotomy with the help of erbium-doped yttrium aluminum garnet (Er: YAG) laser was done to relieve symptoms and to reduce microleakage and increase strength, the fracture line was sealed with the help of Er: YAG laser. The cavity was then sealed with biodentin and composite. For these types of cases, Er: YAG laser is used for biostimulation of exposed pulp, and also to improve strength and reduce microleakage through sealing of fracture line. � 2022 Journal of Interdisciplinary Dentistry.