Browsing by Author "Gupta P.K."
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Item Characterization of Swarna Bhasma and Swarnaprash and Determination of Antimicrobial Properties Against Gut-Pathobiont and Symbiont(Springer, 2024) Singh K.; Gupta P.K.; Kumar A.; Singh B.M.Ayurveda has a long-standing tradition of healthcare in Southeast Asia. Swarnaprash, a classical Ayurveda preparation, is commonly given as the pre-lacteal feed to neonates to prevent labor-related complications and infections. It comprises incinerated gold particles (InAuP/Swarna Bhasma), honey (Madhu), and clarified butter oil (CBO/Cow Ghrita). This in vitro study aimed to evaluate the therapeutic potential of the individual ingredients and combinations of Swarnaprash against selected neonatal gut pathobionts and symbionts. The study employed sophisticated instruments, including SEM with EDAX and X-ray diffraction analysis, to investigate the shape and structural disparities in the ingredients of Swarnaprash. The reported size of gold particles in Swarnaprash ranges from 0.6 to 9.5 �m. These particles are relatively smaller than those in Swarna Bhasma but larger than synthetic gold particles. Swarnaprash demonstrated both bactericidal and bacteriostatic activity against selected neonatal gut pathobionts, with the largest inhibition zones observed for P. aeruginosa and S. Typhi. It surpassed the individual efficacy of its components�Prash, InAuPs, honey, or CBO alone. Notably, Swarnaprash did not affect the selected beneficial gut bacteria. The results warrant further in vivo and clinical studies to explore the effects of Swarnaprash on neonatal gut flora, which would provide vital information for research in neonatal healthcare. � The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.Item Contemporary progress on multifarious coordination polymers for organocatalytic, sensing, and energy-mimetic applications(Elsevier Ltd, 2024) Phukan S.J.; Goswami S.; Sah N.K.; Gupta P.K.; Rai A.; Ghatak T.; Pathak C.; Roy M.; Pai R.K.; Mishra L.; Garai S.Coordination polymers and their subgroup metal�organic frameworks are renowned as the esteemed categories of materials with multifarious properties and possess extensive advantageous applications in the domain of sensing and energy-mimetic applications on account of their expanded surface area, higher charge transfer ability, tunable porous framework, and flexible functionality. This review ruminates on a comprehensive analysis of contemporary outcomes regarding optimized synthetic protocols and structural modulations for various classes of coordination polymers, highlighting their deliberate implications as photoluminescent sensor materials and as energy-mimetic and organoconversion catalysts, along with outlining the significant applicative shortcomings. The additional coordination polymer�assisted exclusive applications have also been discussed, such as the development of ratiometric fluorescent-based probes for specific biological sensing, metal�organic complexes for efficient energy catalysis, and incorporation of bio-inspired photoactive linkers for maximum light harvesting, where the premeditatedly executed frameworks demonstrated augmented results in specialized scientific fields. Finally, a brief overview has been addressed on the effectually applied strategies for assessing electronic mobility, product scalability, and light stability�derived challenges in practical implementations, alongside reviewing the green approaches that expedite sustainable and industrially scalable synthetic pathways consisting potentialities for large-scale outcomes. � 2024 Elsevier LtdItem Effect of Storage Temperature on Microbiological Quality of Optimized Almond Supplemented Paneer Kheer(Agricultural Research Communication Centre, 2024) Gupta P.K.; Pandey R.K.; Panta R.; Rathaur A.; Tinde L.K.Background: The present research entitled Effect of Storage Temperature on Microbiological Quality of Optimized Almond Supplemented Paneer Kheer was conducted to detect the relationship between storage temperature and storage period. Methods: The research took place in the laboratory of Department of Animal Husbandry and Dairying, Banaras Hindu University, Varanasi from October 2019 to December 2019. Three different aspects of Microbiological Parameters were studied viz. Standard Plate Count (SPC), Coliform Count (CFC) and Yeast and Mold Count (YMC) from the sample taken under study as control and optimized. All the samples were studied at distinguish storage temperatures like. 5�C, 25�C and 37�C. The CRD was used to find out the appropriate data obtained from research work. Result: Microbiological parameters have been the major influencer in determination of shelf life of any product. Milk possesses the characteristics to be refrigerated soon otherwise it starts degrading in its quality which is true also for milk products. It has been found that maximum mean scores of SPC of control sample (5.54) and of optimized sample (5.42) were obtained on 3rd day of storage at 37�C. But for YMC maximum mean score of control (1.32) and of optimized (1.25) were obtained on 18th days of storage at 5�C whereas CFC remained nil at every count regardless of storage temperature and period. Thus, the result revealed that with the elevation in the storage temperature along with storage period the life of product deteriorates at a faster rate showing directly proportional relation. � 2024 Agricultural Research Communication Centre. All rights reserved.Item Exploring the role of pomalidomide in androgen-dependent prostate cancer: a computational analysis(Springer Nature, 2024) Pathak S.; Singh V.K.; Gupta P.K.; Mahapatra A.K.; Giri R.; Sahu R.; Sharma R.; Garg N.Prostate cancer (PC) is among the most prevalent cancers in males. It is the leading cause of death in men, in around 48 out of 185 countries. Increased androgen receptor (AR) activity is the key factor contributing to the development or progression of newly diagnosed cases of prostate cancer. Over time, numerous compounds targeting AR have been identified, presenting encouraging avenues for suppressing its hyperactivity. In our investigation, we used the GEPIA tool to study the importance of AR in the context of prostate cancer. This tool integrates the data from TCGA and GTEx in the gene expression pattern analysis and their clinical relevance. This analysis evaluates overall survival, disease-free survival, and transcripts per million (TPM) analysis of AR in PC. We performed docking and simulation for FDA-approved anticancer drugs to assess their potential interactions with the AR. We also conducted a comprehensive analysis of drugs using a quantum calculation (DFT) which provides electronic properties, chemical reactivity, and stability using the HOMO�LUMO energy gap. This study suggests that repurposed synthetic anticancer drugs could be better options for treating prostate cancer by inhibiting AR. In this work, we have shown the potential of pomalidomide, a synthetic anticancer drug, as a potential candidate for androgen-dependent PC treatment. � The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.Item Nanopetal-Assembled SnS Flower-Based Vis-NIR Photodetector(American Chemical Society, 2024) Gupta P.K.; Goswami Y.P.; Pandey A.This paper reports a simple, low-cost, and high-performance two-dimensional (2D) nanopetal-assembled three-dimensional (3D) SnS flowers/Si heterojunction-based visible-near-infrared (vis-NIR) photodetector (PD). A modified chemical bath deposition (CBD) method was used to grow a uniform and closely spaced array of SnS flowers on a Si substrate. This type of nanostructure offers a large photoactive area, thus generating a large number of carriers. The high-performance parameters of the fabricated PD (responsivity, 68.21 A/W; external quantum efficiency (EQE), 1.32 � 104%; detectivity, 6.87 � 1013 Jones; rise time, 193.91 ms; and fall time, 94.19 ms at 635 nm) are attributed to the heterojunction characteristics resulting from closely spaced nanopetal-assembled SnS flowers on silicon. � 2024 American Chemical Society.Item NiO Nanomaterial Functionalized with Organic Gel Molecules for Heterogeneous Asymmetric Catalysis(American Chemical Society, 2024) Gupta P.K.; Kumar N.; Naik K.; Parmar A.S.; Ranganath K.V.Chiral inorganic nanomaterials have a wide range of applications including sensing, catalysis, and electronics. Low molecular weight chiral organogels are widely used in organic fluids, pharmaceuticals, drug delivery, self-assembled materials, electrolytes, and liquid crystals. In this study, we report the synthesis of chiral organogels that mimic the properties of Bingham pseudoplastic with Herschel-Bulkley consistency. Furthermore, chiral NiO nanoparticles were prepared in the presence of chiral gels. The development of chiral enantiomerically pure solids for heterogeneous asymmetric catalysis is of great importance in the pharmaceutical industry. The synthesized chiral material can effectively catalyze the asymmetric Michael addition of malonates with chalcones in high yields and with excellent enantioselectivity. The potential of our catalyst was verified by recycling the catalyst in the asymmetric reaction for a number of times. � 2024 American Chemical Society.Item Quantitative assessment of irrigation water and organic/inorganic amendment on biometric growth profiles of Abelmoschus esculentus and Solanum lycopersicum and their varieties(IWA Publishing, 2024) Mahajan M.; Singh R.P.; Gupta P.K.; Chelliapan S.In recent decades, the use of chemical fertilizers has been recklessly provoked to meet the increased food needs of the rapidly growing population. However, there is some disagreement about the use of chemical fertilizers in agriculture. Hence, the appropriate nitrogen, phosphate, and potassium ratios must be determined before their application in agricultural practices. This study explored three distinct sources of nutrients to support healthy seed germination and reduce nutrient loss: chemical fertilizers, vermicompost, and nutrient-laden irrigation water supply. A sustainable, affordable, and green petri plate seed germination experiment was used to analyze the biometric growth patterns of two plant species (Abelmoschus esculentus and Solanum lycopersicum). To quantify the effects of different irrigation water sources (groundwater, river water), their combinations with chemical fertilizers and vermicompost (3 ton/ha), multivariate statistical methods such as correlation, principal component analysis, and deep neural networks were used. The purpose of this research was to find the optimal nutrient delivery technique for encouraging healthy plant growth while minimizing the environmental stress of excessive nutrient application. � 2024 The Authors.Item Synthesis of fluorescent carbon dots using bio-waste powder for photo-degradation of dyes: simulation and mechanistic study(Royal Society of Chemistry, 2024) Gupta P.K.; Ranganath K.V.S.Biowaste-derived carbon quantum dots (CQDs) offer a wide range of applications, including bioimaging, drug degradation and manufacturing of sensors, photodetectors and photosensitisers. However, inaccurate measurements of their quantum confinement and valence/conduction band potentials complicate their application predictability. Herein, we report carbon dots synthesized hydrothermally (600 �C; 6 h) using sugarcane bagasse powder (SC-CQDs). These SC-CQDs were characterized through UV-visible, fluorescence, PXRD, XPS, DLS, FTIR, Raman, SEM, EDAX and TEM analyses. The obtained SC-CQDs resemble amorphous N-doped multilayer-nanographene-type spherical particles with a size of 9.09 nm and has a band gap of 2.46 eV (?abs: 298 nm) with -COOH/-OH functionalities. The quantum confinement and valence/conduction band potentials were estimated using Brus-Kayanuma quantum mechanical (BKQM) and virtual molecular dynamics (VMD) equations. These CQDs are potential candidates for sunlight-mediated methylene blue degradation in water within 36 min for up to four catalytic cycles. � 2024 The Royal Society of Chemistry.Item Understanding the benefits and implications of irrigation water and fertilizer use on plant health(Springer Science and Business Media B.V., 2024) Mahajan M.; Singh A.; Singh R.P.; Gupta P.K.; Kothari R.; Srivastava V.Shrinking agricultural land sizes and multiplied food demand have prompted overuse of fertilizers in agriculture, leading to a series of environmental repercussions worsening day after day. In the contemporary scenario, concerns over the magnitude of soil destruction and plant health have shifted the scientific community's attention toward sustainable agricultural practices, including organic farming and the use of organic fertilizers like vermicompost (VC), animal manure, etc. A factorial study using a randomized block design was conducted in the field to appraise the potential of fertilizer and irrigation water on the biochemical and growth responses of Abelmoschus esculentus using different doses of VCs along with and without recommended doses of NPK. All the biochemical analyses were performed at 45 and 65 DAG (days after germination). At both ages, combination of 3-ton ha?1 vermicompost + recommended dose of inorganic fertilizer (120:60:60�kg�ha?1) + irrigation water treatments (T5) had the highest protein, chlorophyll, carotenoid, and phenol content and less lipid peroxidation as compared to control (144.28%, 84.21%, 83%, 224.2% and -60.43%, respectively). Also, T5 treatment showed a noticeable increase in the photosynthetic pigments level and reduced heavy metal content in fruits of the test plant at maturity. Statistical analyses, including PCA, Pearson correlation matrix, and MANOVA (p < 0.05), showed that appropriate dosing of VC together with inorganic fertilizer not only augments plant growth and yield, but also helps in reducing the transport of metals to different plant parts, mitigating food chain contamination. However, overdosing on fertilizers could negatively impact the plant�s growth and yield. Overall, the research highlights the value of organic agricultural supplements and irrigation water quality, fostering sustainable agriculture in multifaceted ways. Graphical abstract: (Figure presented.) � The Author(s), under exclusive licence to Springer Nature B.V. 2023.
