Browsing by Author "Kumar, Prasanna"

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    Factors associated with unexplained sudden deaths among adults aged 18-45 years in India � A multicentric matched case�control study
    (Wolters Kluwer Medknow Publications, 2023) Ponnaiah, Manickam; Bhatnagar, Tarun; Abdulkader, Rizwan Suliankachi; Elumalai, Rajalakshmi; Surya, Janani; Jeyashree, Kathiresan; Kumar, Muthusamy Santhosh; Govindaraju, Ranjithkumar; Thangaraj, Jeromie Wesley Vivian; Aggarwal, Hari Krishan; Balan, Suresh; Baruah, Tridip Dutta; Basu, Ayan; Bavaskar, Yogita; Bhadoria, Ajeet Singh; Bhalla, Ashish; Bhardwaj, Pankaj; Bhat, Rachana; Chakravarty, Jaya; Chandy, Gina Maryann; Gupta, Bal Kishan; Kakkar, Rakesh; Karnam, Ali Hasan Faiz; Kataria, Sushila; Khambholja, Janakkumar; Kumar, Dewesh; Kumar, Nithin; Lyngdoh, Monaliza; Meena, M. Selva; Mehta, Kedar; Sheethal, M.P.; Mukherjee, Subhasis; Mundra, Anuj; Murugan, Arun; Narayanan, Seetharaman; Nathan, Balamurugan; Ojah, Jutika; Patil, Pushpa; Pawar, Sunita; Pon Ruban, A. Charles; Vadivelu, R.; Rana, Rishabh Kumar; Boopathy, S. Nagendra; Priya, S.; Sahoo, Saroj Kumar; Shah, Arti; Shameem, Mohammad; Shanmugam, Karthikeyan; Shivnitwar, Sachin K.; Singhai, Abhishek; Srivastava, Saurabh; Sulgante, Sudheera; Talukdar, Arunansu; Verma, Alka; Vohra, Rajaat; Wani, Rabbanie Tariq; Bathula, Bhargavi; Kumari, Gayathri; Kumar, Divya Saravana; Narasimhan, Aishwariya; Krupa, N.C.; Senguttuvan, Thirumaran; Surendran, Parvathi; Tamilmani, Dharsikaa; Turuk, Alka; Kumar, Gunjan; Murkherjee, Aparna; Aggarwal, Rakesh; Murhekar, Manoj Vasant; Talukdhar, Anjan Jyoti; Das, Raj Prathim; Bhattacharyya, Pranab Jyoti; Barman, Pankaj Jyoti; Das, Partha Pratim; Lakshmi, P.V.M.; Panday, Naveen; Pannu, Ashok Kumar; Dhibar, Debaprasad; Kanauje, Pankaj Kumar; Singh, Satyajit; Siddiqui, Sabah; Borkar, Nitin Bhajandas; Adalja, Mayur; Godbole, Sandip Shah Varsha; Raj, Rikin; Shah, Nehal; Suthar, Nilay; Purohit, Hemang; Patel, Bhargav; Pathkjee, Rutika; Pandit, Niraj; Shah, Siddharth; Patel, Bhavesh; Agrawal, Anuja; Jain, Deepak; Bansal, Manish; Deswal, Vikas; Sharma, Pooja; Siraj, Farhana; Rashid, Aamir; Fazili, Anjum Bashir; Bhattacharya, Pradip Kumar; Birua, Hirendra; Prasad, Manoj Kumar; Singh, Shashi Bhushan; Ojha, Umendra Kumar; Jha, Ravi Ranjan; Manuja, L.M.; Raghavendra, S.K.; Hugar, Vijay; Radha, R.; Kesari, Pallavi; Tapse, Sunil; Avate, Ambrish; Kumar, Prasanna; Unnikrishnan, Bhaskaran; Rekha, T.; Basavaprabhu, A.; Rao, Mithun; Ravindra, Prithvishree; Rao, Chythra R.; Balakrishnan, Jayaraj Mymbilly; Palimar, Vikram; Ashwini, S.; Hiremath, Bhavana; Malapur, Rajnikanth; Joshi, Ankur; Nagar, Manoj; Keche, Atul S.; Kakrani, Arjun Lal; Kanitkar, Shubhangi; Tripathy, Srikanth; Mahajan, Savita; Shinde, Akshada; Patil, Sunil; Gaikwad, Vijay; Lokhande, Ganesh; Ganeriwal, Astha; Wasnik, Ramesh; Kalantri, Ashwini; Bhandari, Dhiraj; Salunkhe, Preetam; Raut, Abhishek; Pala, Star; Lynrah, K.G.; Lyngdoh, Nari; Thabah, Rajani; Kapoor, Manish; Barik, Sadananda; Mohanty, Chitta Ranjan; Subba, Sonu Hangma; Guru, Satyabrata; Ayyan, Manu; Kar, Sitanshu Sekhar; Maroju, Nanda Kishore; Kumar, Naveen; Mohandas, Roselin; Tamilselvan, Charulatha; Rajaram, Saranya; Kankaria, Ankita; Mirza, Moonis; Dhoat, Preeti Singh; Shergill, Jaspreet; Gupta, Manoj Kumar; Goel, Akhil Dhanesh; Rohila, Amit Kumar; Meena, Durga Shankar; Paliwal, Archana; Gahlot, Niti; Sharma, Nikita; Kumar, Harkesh; Choudhary, Dinesh; Meena, Shyam Lal; Bhambhu, Dinesh; Gupta, Jigyasa; Priya, G.; Samuel, Sonia; Bagyalakshmi, S.; Kumar T, Sathish; Mohamed, Aazmi; Kumar, G. Rathna; Rajesh, A.; Rajendran, V.; Soorya, M.; Sridevi, P.N.; Karthika, A.; Kumari, K. Santha Sheela; Kumar, K. Sathish; Gnanavel, Pavithra; Ramesh, Dasarathan; Gunasekaran, Aravind; Kaverikannan, R.; Manohar, Madhumitha; Sofia, P.; Abishek, R.; Shanmugam, Jeevithan; Kumar, Mohan; Periyasamy, Aparnavi; Kumar, Dhilipan; Selvarani, G.; Ramasamy, Thirukumaran; Suresh, N.; Alagappan, Kannan Muthuraman; Vijayageetha, Mathavasami; Ramalingam, Sudha; Velammal, Petchiappan; Subramani, Yamini; Marappa, Lakshmi; Pandurangan, Viswanathan; Muralidharan, T.R.; Rajkumar, M.; Ramasamy, Senthil Murugan; Trupti, Bodhare; Rajh, Bharath; Reddy, Duvuru Amareswar; Upadhyay, Rashmi; Srivastava, Anurag; Gupta, Rakesh; Bhattnagar, Ranjan; Chaubey, Manaswi; Ghosh, Soumik; Kumar, Nilesh; Azharuddin, Mohammad; Khan, Nafees A.; Aslam, Mohammad; Mahmood, Asad; Singh, R.K.; Yadav, Priyank; Kapoor, Aditya; Sanjeev, Om Prakash; Sundar, Shyam; Panda, Prasan Kumar; Bairwa, Mukesh; Gehlot, Mahendera Singh; Bhadoria, Pooja; Chakravorty, Arup; Chakravorty, Sarmistha; Ray, Arindam; Dhua, Aparup; Pal, Amitava; Ghosh, Priyanka; Roy, Yogiraj; Dutta, Sinjita; Basu, Subhro Samujjal
    Background & objectives: In view of anecdotal reports of sudden unexplained deaths in India�s apparently healthy young adults, linking to coronavirus disease 2019 (COVID-19) infection or vaccination, we determined the factors associated with such deaths in individuals aged 18-45 years through a multicentric matched case�control study. Methods: This study was conducted through participation of 47 tertiary care hospitals across India. Cases were apparently healthy individuals aged 18-45 years without any known co-morbidity, who suddenly (<24 h of hospitalization or seen apparently healthy 24 h before death) died of unexplained causes during 1st October 2021-31st March 2023. Four controls were included per case matched for age, gender and neighborhood. We interviewed/perused records to collect data on COVID-19 vaccination/infection and post-COVID-19 conditions, family history of sudden death, smoking, recreational drug use, alcohol frequency and binge drinking and vigorous-intensity physical activity two days before death/interviews. We developed regression models considering COVID-19 vaccination ?42 days before outcome, any vaccine received anytime and vaccine doses to compute an adjusted matched odds ratio (aOR) with 95 per cent confidence interval (CI). Results: Seven hundred twenty nine cases and 2916 controls were included in the analysis. Receipt of at least one dose of COVID-19 vaccine lowered the odds [aOR (95% CI)] for unexplained sudden death [0.58 (0.37, 0.92)], whereas past COVID-19 hospitalization [3.8 (1.36, 10.61)], family history of sudden death [2.53 (1.52, 4.21)], binge drinking 48 h before death/interview [5.29 (2.57, 10.89)], use of recreational drug/substance [2.92 (1.1, 7.71)] and performing vigorous-intensity physical activity 48 h before death/interview [3.7 (1.36, 10.05)] were positively associated. Two doses lowered the odds of unexplained sudden death [0.51 (0.28, 0.91)], whereas single dose did not. Interpretation & conclusions: COVID-19 vaccination did not increase the risk of unexplained sudden death among young adults in India. Past COVID-19 hospitalization, family history of sudden death and certain lifestyle behaviors increased the likelihood of unexplained sudden death. � 2023 Indian Journal of Medical Research, published by Wolters Kluwer - Medknow for Director-General, Indian Council of Medical Research.