Browsing by Author "Kumar, Susheel"

Now showing 1 - 4 of 4
  • Thumbnail Image
    Publication
    Fungal and mycotoxin contamination of herbal raw materials and their protection by nanoencapsulated essential oils: An overview
    (Elsevier Ltd, 2022) Singh, Bijendra Kumar; Tiwari, Shikha; Maurya, Akash; Kumar, Susheel; Dubey, Nawal Kishore
    Presently, consumption of herbal raw materials (HRMs) has been an emerging concern owing to therapeutic potential against broad range of human diseases. However, there are various cases available reporting the fungal and mycotoxin contaminations. These HRMs after collection undergo severe extent of deterioration, leading to degradation of their active principles. Different chemical preservatives have been frequently used to protect HRMs from fungal and mycotoxin contamination, however, their indiscriminate use could lead to adverse effects on human health and environment due to residual toxicity. The use of essential oils (EOs) based formulations has been recommended as a green alternative of synthetic preservatives having greater safety profile and biodegradable nature. Nanoencapsulation maintains the stability of EOs and facilitate the controlled delivery with improvement in maintenance of bioactive principles of HRMs against fungal and mycotoxin mediated biodeterioration to boost pharmaceutical sectors. This review summarizes the pharmacological properties of some HRMs, the extent of degradation by fungal and mycotoxin contamination, preservation through nanoencapsulated EOs, mode of action, patenting of EOs as preservatives, and finally future opportunities to mitigate the associated problems. � 2021 Elsevier Ltd
  • Thumbnail Image
    Publication
    Mechanistic investigations on antifungal and antiaflatoxigenic activities of chemically characterised Carum carvi L. essential oil against fungal infestation and aflatoxin contamination of herbal raw materials
    (Taylor and Francis Ltd., 2022) Maurya, Akash; Kumar, Susheel; Singh, Bijendra Kumar; Chaudhari, Anand Kumar; Dwivedy, Abhishek Kumar; Prakash, Bhanu; Dubey, Nawal Kishore
    This study aimed to investigate the efficiency of chemically characterised Carum carvi essential oil (CcEO) against aflatoxin B1 (AFB1) producing strain of Aspergillus flavus (AF-LHP-WS-4) causing deterioration of herbal raw materials (HRM). GC-MS analysis of the EO revealed the presence of carvone (69.85%) as a dominant component. CcEO caused complete suppression of A. flavus growth and AFB1 secretion at 0.7 and 0.6 �L/mL, respectively. The investigation on antifungal mode of action showed that CcEO inhibited fungal growth via abrogating ergosterol biosynthesis and triggered efflux of vital cellular ions. The inhibition of AFB1 biosynthesis was attributed to the inhibition of cellular methylglyoxal (MG) biosynthesis. In addition, CcEO showed remarkable antioxidant activity (IC50 = 10.564 �L/mL) against DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals. Based on overall results, it can be concluded that the CcEO may be recommended as potential antifungal agent for protection of HRM from fungal infestation and AFB1 contamination. � 2021 Informa UK Limited, trading as Taylor & Francis Group.
  • Thumbnail Image
    Publication
    On generalized carleson operator with application in walsh type wavelet packet expansions
    (Chiang Mai University, 2021) Lal, Shyam; Kumar, Susheel
    In this paper, two new theorems on generalized Carleson operator for a Walsh type wavelet packet system and for periodic Walsh type wavelet packet expansion of a function f ? Lp [0, 1), 1 < p < ?, have been established. � 2021 by TJM. All rights reserved.
  • Thumbnail Image
    Publication
    Turonian (Late Cretaceous) Heterodont Subfamilies: Lucininae, Eriphylinae and Opinae (Bivalvia: Veneroida) from the Narmada Basin, central India
    (Palaeontological Society Of India, 2021) Jaitly, A.K.; Kumar, Susheel; Pandey, Bindhyachal; Gautam, J.P.; Tiwari, Deep Narayan
    Eight species belonging to the genera/subgenera Lucina, Parvilucina (Microloripes), Callucina, Eriphyla (Lyapinella), Crassatellina and Opis of the three subfamilies Lucininae, Eriphylinae and Opinae have been reported here from the Turonian (Late Cretaceous) of Narmada Basin, India. Out of these, the two species Crassatellina minuta and Opis reticulata have been newly created. The overall characters of the subfamily Opinae, the genus Callucina and the subgenus Eriphyla (Lyapinella) have also been reviewed here. � 2021 Palaeontological Society Of India. All rights reserved.