Browsing by Author "Mahajan, Arjun"

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    Effects of curcumin on oral cancer at molecular level: A systematic review
    (Wolters Kluwer Medknow Publications, 2023) Singh, Akhilesh Kumar; Sharma, Naresh Kumar; Mishra, Nitesh; Mahajan, Arjun; Krishnan, Aswathi; Rajpoot, Ravina; Kumar, Janani Anand; Pandey, Arun
    This systematic review mainly focuses on the effects of curcumin on oral cancer cells at the molecular level and summarizes the results of the studies. We searched and analyzed various databases such as Pub Med, ProQuest, Google Scholar, Science Direct, and Scopus. Searches were conducted from 2006 to 2021. This systematic review evaluated various effects of curcumin on oral cancer at the molecular level. All the studies related to the effects of curcumin on oral cancer, both in?vivo and in?vitro, were included. After abstract and text screening a total of 13 articles were finally selected for the study based on the inclusion and exclusion criteria. All most all the included studies reported that after treating the cell lines with curcumin there is a reduction in cell proliferation and cell growth, analyzed using MTT (3?(4,5?dimethylthiazol?2?yl)?2,5?diphenyl tetrazolium bromide) assay. Curcumin also induces S phase cell cycle arrest and also prevents Tregs migration. The curcumin reverses the process of epithelial mesenchymal transition (EMT) back to mesenchymal epithelial transition (MET). From this review, it is concluded that curcumin inhibited proliferation, migration, invasion, and metastasis, and induced apoptosis via modulating multiple signaling pathways in oral cancer cell lines. But further clinical trials are needed for a detailed evaluation of the effects of curcumin on patients with oral cancer. � 2023 National Journal of Maxillofacial Surgery.
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    Hara Hara Mahadev (HHM) maneuver: Simple Yet Effective Way of Post-Operative Physiotherapy after Reconstruction with Pectoralis Major Myo-cutaneous Flap in Oral Cancer Defects
    (Springer, 2023) Mahajan, Arjun; Singh, Akhilesh Kumar; Sharma, Naresh Kumar
    Introduction: Pectoralis major myo-cutaneous flap remains time-tested work horse for reconstruction of postsurgical oral cancer defects despite of popularity of free flaps. But postoperatively majority of attention is provided to recipient site and its complications and donor site complications are often overlooked. Reduced post-operative mobility of shoulder joint and drooping shoulder� after injury to spinal accessory nerve being the most commondonor site morbidities. Method: To overcome this complication, we have introduced a novel Physiotherapeutic maneuver named �Hara Hara Mahadev� (HHM) Maneuver. Wherein postoperatively patients were advised to do this novel physiotherapeutic maneuver regularly. Results: With continued practice encouraging results with drastic increase in range of motion and shoulder mobility was observed. � 2023, The Association of Oral and Maxillofacial Surgeons of India.
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    Oral Manifestations of Malignant Immunoglobinopathy Hidden in Plain Sight - A Rare Case Report
    (Wolters Kluwer Medknow Publications, 2023) Sharma, Naresh Kumar; Singh, Akhilesh Kumar; Hirani, Mehul Shashikant; Krishnan, Aswathi; Mahajan, Arjun; Rajpoot, Ravina
    Rationale: Radiolucent lesions over the angle-body region of the mandible are frequently difficult to diagnose but crucial to provide patient-centred care. Patient Concerns: An elderly female presented with a painless slow-growing swelling over her left lower face for one year, radiographically appearing as a well-defined unilocular radiolucency over the left body of the mandible. Diagnosis: Aspiration was negative, and biopsy was inconclusive. Further imaging, bone marrow biopsy, immune profile and serum electrophoresis confirmed the diagnosis of multiple myeloma. Treatment: She was referred to Medical Oncology for chemotherapy of lenalidomide, bortezomib and dexamethasone regimen cycle that was repeated every 21 days. Outcomes: There was no increase in swelling, and radiographically 'punched-out' lesions were reduced significantly. Take-Away Lessons: Maxillofacial clinicians should be attentive to the oral manifestations of underlying disease, have a high index of suspicion and start the treatment promptly to increase chances of a favourable outcome. � 2023 Annals of Maxillofacial Surgery.