Browsing by Author "Rao, Vishnu Vardhan"

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    Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study
    (Wolters Kluwer Medknow Publications, 2021) Kumar, Gunjan; Mukherjee, Aparna; Sharma, Ravendra K.; Menon, Geetha R.; Sahu, Damodar; Wig, Naveet; Panda, Samiran; Rao, Vishnu Vardhan; Singh, Sujeet; Guleria, Randeep; Bhargava, Balram; Pakhare, Abhijit; Joshi, Rajnish; Bhuniya, Sourin; Panigrahi, Manoj Kumar; Bhardwaj, Pankaj; Misra, Sanjeev; Gupta, Manoj; Goel, Akhil D.; Mundadan, Netto George; Khan, Adil Rashid; Soneja, Manish; Baruah, Tridip Dutta; Kannauje, Pankaj Kumar; Kumar, Ajit; Yadhav, Kala M.L.; Kumar, Manoj; John, Mary; Mohan, Sangeetha; Patel, Amit; Madan, Surabhi; Mukherjee, Subhasis; Pal, Amitava; Banerjee, Saikat; Shah, Arti D.; Rana, Yash; Madharia, Arun; Madharia, Ankit; Bandaru, Rajiv Kumar; Mavoori, Archana; Dube, Simmi; Nahar, Nitin; Bingi, Thrilok Chander; Mesipogu, Rajarao; Aedula, Vinaya Sekhar; Panchal, Manisha; Mohammedrafiq, Mansuri Amirsohil; Upadhyay, Rashmi; Srivastava, Saurabh; Salgar, Veeresh B.; Desai, Rizwan; Kikon, Nyanthung; Kikon, Rhondemo; Sarangi, Lisa; Rath, Mahesh; Agarwal, Anup; Turuk, Alka; Sharma, Lokesh Kumar; Anand, Tanu; Bhatnagar, Tarun; Ghosh, Saumitra; Hazra, Avijit; Ray, Yogiraj; Ray, Rammohan; Patnaik, Lipilekha; Sahoo, Jagdish Prasad; Chakravarty, Jaya; Kansal, Sangeeta; Shameem, Mohammad; Fatima, Nazish; Kumar, M. Pavan; Rao, Bikshapathi; Himanshu, D.; Kumar, Amit; Dulhani, Naveen; Toppo, Amar Deepak; Sharma, Nikita; Vohra, Rajat; Kataria, Sushila; Sharma, Pooja; Talukdar, Arunansu; Dasgupta, Gargi; Desai, Anita; Nityasri, S.N.; Panchal, Yashmin; Manohar, K.; Raju, Y.S.; Pala, Star; Jamil, Md.; Katyal, V.K.; Goyal, Sandeep; Ojha, U.K.; Jha, Ravi Ranjan; Bhalla, Ashish; Puri, G.D.; Samita, S.; Suri, Vikas; Mohindra, Ritin; Pathak, Ashish; Sharma, Ashish; Khambholja, Janakkumar R.; Shah, Nehal M.; Palat, Paltial N.; Rajvansh, Kruti; Bhandari, Sudhir; Agrawal, Abhishek; Gupta, Bal Kishan; Gupta, Jigyasa; Choudhury, Ratnamala; Rao, Mangala; Chatterji, Soumyadip; Mukherjee, Sudipta
    Background & objectives: India witnessed a massive second surge of COVID-19 cases since March 2021 after a period of decline from September 2020. Data collected under the National Clinical Registry for COVID-19 (NCRC) were analysed to describe the differences in demographic and clinical features of COVID-19 patients recruited during these two successive waves. Methods: The NCRC, launched in September 2020, is an ongoing multicentre observational initiative, which provided the platform for the current investigation. Demographic, clinical, treatment and outcome data of hospitalized, confirmed COVID-19 patients were captured in an electronic data portal from 41 hospitals across India. Patients enrolled during September 1, 2020 to January 31, 2021 and February 1 to May 11, 2021 constituted participants of the two successive waves, respectively. Results: As on May 11, 2021, 18961 individuals were recruited in the registry, 12059 and 6903 reflecting in-patients from the first and second waves, respectively. Mean age of the patients was significantly lower in the second wave [48.7 (18.1) yr vs. 50.7 (18.0) yr, P<0.001] with higher proportion of patients in the younger age group intervals of <20, and 20-39 yr. Approximately 70 per cent of the admitted patients were ? 40 yr of age in both waves of the pandemic. The proportion of males were slightly lower in second wave as compared to the first [4400 (63.7%) vs. 7886 (65.4%), P=0.02]. Commonest presenting symptom was fever in both waves. In the second wave, a significantly higher proportion [2625 (48.6%) vs. 4420 (42.8%), P<0.003] complained of shortness of breath, developed ARDS [422(13%) vs. 880 (7.9%), P<0.001], required supplemental oxygen [1637 (50.3%) vs. 4771 (42.7%), P<0.001], and mechanical ventilation [260 (15.9%) vs. 530 (11.1%), P<0.001]. Mortality also significantly increased in the second wave [OR: 1.35 (95% CI: 1.19, 1.52)] in all age groups except in <20 yr. Interpretation & conclusions: The second wave of COVID-19 in India was slightly different in presentation than the first wave, with a younger demography, lesser comorbidities, and presentation with breathlessness in greater frequency. � 2021 BioMed Central Ltd.. All rights reserved.