Browsing by Author "Saha, Pallavi"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
Publication 7-Azaspiroketal as a unique and effective auxochrome moiety: demonstration in a fluorescent coumarin dye and application in cell imaging(Royal Society of Chemistry, 2023) Indurthi, Harish K.; Goswami, Pooja; Das, Samarpita; Saha, Pallavi; Koch, Biplob; Sharma, Deepak K.Replacement of electron-donating N,N-dialkyl groups with azacyclic groups has been described as a promising auxochrome to improve the low fluorescent quantum yields (?F) of conventional fluorophores. However, the insufficient brightness and poor solubility of fluorophores pose a significant bottleneck for bioimaging. A new type of fluorescent coumarin dye was designed and synthesized using 7-azaspiroketals as the electron-donating auxochrome group. Such modifications resulted in high-quality coumarin fluorophores with improved solubility and brightness. To the best of our knowledge, this is the first report of using apex-N-substituted azaspiroketals as an electron donor group in any class of donor-acceptor dye. Furthermore, the successful application of these new dyes in biological imaging for living cells has been demonstrated. � 2023 The Royal Society of Chemistry.
