Browsing by Author "Sequeira J.J."

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    Correction to: Genetic evidence for a single founding population of the Lakshadweep Islands (Molecular Genetics and Genomics, (2024), 299, 1, (8), 10.1007/s00438-024-02110-z)
    (Springer Science and Business Media Deutschland GmbH, 2024) Kumar S.; Singh P.P.; Pasupuleti N.; Shendre S.S.; Sequeira J.J.; Babu I.; Mustak M.S.; Rai N.; Chaubey G.
    In this article the author name Mohammed S. Mustak was incorrectly written as Mohammed S. Mutak. The original article has been corrected. � The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
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    Exploring the genetic implications of demographic dynamics in Jammu and Kashmir using autosomal STRs
    (Springer Science and Business Media Deutschland GmbH, 2024) Mubarik N.; Ganei M.A.; Dixit S.; Kumawat R.K.; Sequeira J.J.; Ahangar N.A.; Kanth S.A.; Dar I.A.; Mushtaq I.; Mohsin M.; Mustak M.S.; Chaubey G.; Hamid S.; Shrivastava P.
    The Union Territory of Jammu and Kashmir has always been a point of contention among India, Pakistan, and China for various reasons. This region has great significance historically due to its geography and ethnic diversity. However, a comprehensive genetic study providing the genetic landscape of Jammu and Kashmir was lacking until now. In this study, we analysed 21 hyper-variable autosomal STR loci of 694 individuals from Jammu and Kashmir and compared them with neighbouring populations to explore the genetic implications of demographic dynamics that have taken place in this region. Our findings suggest that the population of Jammu and Kashmir is a genetic mixture of two major clines, northern and southern, that correspond with the variation in geography, linguistics, and demography of the region. Broadly, the gene flow into the southern cline appears to be in historical times perhaps as a result of the spread of Gurjars, Dogri language and invasions of Mongols. However, the arrival of ancient nomadic tribes into this region may belong to the time depth of the arrival of pastoralist communities in this region. As a future perspective, a comprehensive study including samples from individual tribes will provide fine-scale structure of the gene pool of Jammu and Kashmir. � The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
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    Forensic Characterization, Genomic Variability and Ancestry Analysis of Six Populations from Odisha Using mtDNA SNPs and Autosomal STRs
    (Springer, 2024) Sequeira J.J.; Panda M.; Dixit S.; Kumawat R.; Mustak M.S.; Sharma A.N.; Chaubey G.; Shrivastava P.
    Located on India's eastern coast, Odisha is known for its diverse tribes and castes. In the early days of genome sequencing technology, researchers primarily studied the Austroasiatic communities inhabiting this region to reconstruct the ancient origins and dispersal of this broad linguistic group. However, current research has shifted towards identifying population and individual-specific genome variation for forensic applications. This study aims to analyze the forensic efficiency and ancestry of six populations from Odisha. We assessed the SF mtDNA-SNP60� PCR Amplification Kit by comparing it with PowerPlex� Fusion 6C System, a widely used autosomal STR (aSTR) kit, in an Indian cohort. Although the mtDNA SNP kit showed low discriminating power for individuals of a diverse population, it could identify deep lineage divergence. Also, we utilized mitochondrial and autosomal variation information to analyze the ancestry of six endogamous ethnic groups in Odisha. We observe two extremities�populations with higher West Asian affinity and those with East Asian affinity. This observation is in congruence with the existing information of their tribal and non-tribal affiliation. When compared with neighbouring populations from Central and Eastern India, multivariate analysis showed that the Brahmins clustered separately or with the Gopala, Kaibarta appeared as an intermediate, Pana and Kandha clustered with the Gonds, and Savara with the Munda tribes. Our findings indicate significant deep lineage stratification in the ethnic populations of Odisha and a gene flow from West and East Asia. The artefacts of unique deep lineage in such a diverse population will help in improving forensic identification. In addition, we conclude that the SF mtDNA-SNP60 PCR Amplification Kit may be used only as a supplementary tool for forensic analysis. � The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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    Genetic evidence for a single founding population of the Lakshadweep Islands
    (Springer Science and Business Media Deutschland GmbH, 2024) Kumar S.; Singh P.P.; Pasupuleti N.; Shendre S.S.; Sequeira J.J.; Babu I.; Mutak M.S.; Rai N.; Chaubey G.
    Lakshadweep is an archipelago of 36 islands located in the Southeastern Arabian Sea. In the absence of a detailed archaeological record, the human settlement timing of this island is vague. Previous genetic studies on haploid DNA makers suggested sex-biased ancestry linked to North and South Indian populations. Maternal ancestry suggested a closer link with the Southern Indian, while paternal ancestry advocated the Northern Indian genetic�affinity. Since the haploid markers are more sensitive to genetic drift, which is evident for the Island populations, we have used the biparental high-resolution single-nucleotide polymorphic markers to reconstruct the population history of Lakshadweep Islands. Using the fine-scaled analyses, we specifically focused on (A) the ancestry components of Lakshadweep Islands populations; (B) their relation with East, West Eurasia and South Asia; (C) the number of founding lineages and (D) the putative migration from Northern India as the paternal ancestry was closer to the North Indian populations. Our analysis of ancestry components confirmed relatively higher North Indian ancestry among the Lakshadweep population. These populations are closely related to the South Asian populations. We identified mainly�a single founding population for these Islands, geographically divided into two sub-clusters. By examining the population�s genetic composition and analysing the gene flow from different source populations, this study contributes to our understanding of Lakshadweep Island�s evolutionary history and population dynamics. These findings shed light on the complex interactions between ethnic groups and their genetic contributions in making the Lakshadweep population. � The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.