Browsing by Author "Sharma, Saurabh"

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    Modeling of rupture using strong motion generation area: a case study of Hualien earthquake (M w 6.1) occurred on April 18, 2019
    (Springer Science and Business Media Deutschland GmbH, 2023) Sharma, Saurabh; Joshi, Anand; Sandeep; Lin, Che-Min; Kuo, Chun-Hsiang; Wen, Kuo-Liang; Singh, Sandeep; Sharma, Mukat Lal; Pandey, Mohit; Singh, Jyoti
    The strong Hualien earthquake (Mw 6.1) occurred along the suture zone of the Eurasian Plate and the Philippine Sea Plate, which struck�the Hualien city in eastern Taiwan on April 18, 2019. The focal mechanism of this earthquake shows that it is caused by a rupture within a thrust. In the present study, the rupture plane responsible for this earthquake has been modeled using the modified semi-empirical technique (MSET). The whole rupture plane is assumed to be composed of strong motion generation areas (SMGAs) along which the slip occurs with large velocities. The spatiotemporal distribution of aftershocks of this earthquake within identified rupture plane suggests that there are two SMGAs within the rupture plane. The source displacement spectra (SDS) obtained from the observed records have been used to compute the source parameters of these two SMGAs. The MSET efficiently simulates strong ground motion (SGM) at the rock site. The shallow subsurface shear wave velocity profile at various stations has been used as an input to SHAKE91 algorithm for converting records at the surface to that at the rock site. The simulated records are compared with the observed records based on root-mean-square error (RMSE) in peak ground acceleration (PGA) of horizontal components. Various parameters of the rupture plane have been selected using an iterative forward modeling scheme. The accelerograms have been simulated for all the stations that lie within an epicentral distance ranging from 5 to 100�km using the final rupture plane parameters. The comparison of observed and synthetic records validates the effectiveness of the simulation technique and suggests that the Hualien earthquake consists of two SMGAs responsible for high-frequency SGM. � 2022, The Author(s) under exclusive licence to Institute of Geophysics, Polish Academy of Sciences & Polish Academy of Sciences.
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    Prevalence of HLA-B*57:01 allele in HIV-positive and HIV-negative population of eastern India: An epidemiological study
    (Elsevier B.V., 2022) Gautam, Abhilasha; Chakravarty, Jaya; Chourasia, Ankita; Sharma, Saurabh; Sarkar, Tanmoy; Das, Parimal
    Introduction: The nucleoside analogue reverse-transcriptase inhibitor Abacavir has potent antiviral activity against HIV; however, 5�8% patients develop hypersensitivity reactions within six weeks of treatment. The presence of the HLA-B*57:01 allele is strongly associated with the risk of Abacavir-associated hypersensitivity reaction (ABC-HSR). Prevalence of HLA-B*57:01 allele varies in different populations. This observational study was performed to determine the prevalence of HLA-B*57:01 allele in the population of Eastern India which included both HIV-positive and HIV-negative subjects. Methods: We screened 406 subjects attending the ART (antiretroviral treatment) centre and linked ICTC (Integrated counselling and testing centre), however 6 samples did not have adequate DNA. HLA-B*57:01 typing was done using direct sequence specific primer PCR (SSP-PCR). All PCR positive samples were sequenced using Sanger's method. Results: The prevalence of HLA-B*57:01 genotype in our cohort was 12.25% (49/400). Prevalence among men was 13.3% (33/248) and female was 10.5% (16/152). The prevalence was similar in HIV-positive subjects (13.5%) and in HIV-negative subjects (11%). Conclusions: Prevalence of HLA-B*57:01 in our eastern Indian population was high. Therefore, screening for HLA-B*57:01 before ABC administration would be useful to prevent ABC-HSR. � 2022