Browsing by Author "Sharma S.K."

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    A highly selective coumarin-based chemosensor for dual sensing of Cu2+ and Zn2+ ions with logic gate integration and live cell imaging
    (Royal Society of Chemistry, 2024) Singh A.K.; Singh A.K.; Sharma S.K.; Sonkar V.K.; Singh V.P.
    In this paper, a coumarin-based Schiff base chemosensor has been synthesized and developed to detect Cu2+ and Zn2+ ions in nanomolar concentrations. The probe selectively distinguishes Cu2+ and Zn2+ from among several metal ions in DMF : H2O (7 : 3, v/v, pH 7.4) HEPES buffer. The structure of the probe and its sensing behavior were investigated by FT-IR, UV-vis, fluorescence, HRMS, and NMR analyses, along with X-ray crystallography and computational studies. CIH detects Zn2+ and Cu2+ using different strategies: CHEF-induced fluorescence enhancement and paramagnetic fluorescence quenching, respectively. Job's plots show a 1 : 1 binding interaction between CIH and Cu2+ or Zn2+ ions. The binding constant values for Cu2+ (1.237 � 105 M?1) and Zn2+ (1.24 � 104 M?1) suggest a better ability for Cu2+ to interact with CIH than Zn2+. An extremely high sensitivity of the probe was highlighted by its very low detection limits (LOD) of 5.36 nM for Cu2+ and 3.49 nM for Zn2+. The regeneration of the probe with the addition of EDTA in its complexes allows the formation of molecular logic gates. CIH has been successfully employed in mitotracking and intracellular detection of Zn2+ and Cu2+ in SiHa cells. � 2024 The Royal Society of Chemistry.
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    Potential of Indian agriculture for capturing atmospheric CO2 and monetizing carbon credits to the farmers: An overview and policy framework
    (Academic Press Inc., 2024) Meena R.S.; Lal R.; Kumar S.; Pradhan G.; Srinivasarao C.; Singh A.K.; Pathak H.; Abhilash P.C.; Kumar A.; Sharma S.K.; Jat M.L.; Singh S.
    The potential of Indian agriculture in atmospheric CO2 capture and its role in enabling farmers to monetize C credits is critical to climate change mitigation strategies. This potential is especially significant given the vast and diverse agricultural landscapes across India, which inherently possess the capacity for considerable C sequestration. The realization of this potential hinges on the establishment of a comprehensive policy framework. Essential components of this framework include methodologies for accurate measurement, reporting, and verification (MRV) of C sequestration. To fully harness the potential of Indian agriculture in atmospheric CO2 capture and C credit monetization, future endeavors should focus on developing integrated technological solutions, and collaborative efforts are the cornerstone for accurate C measurement and verification, alongside formulating inclusive policies that specifically support small-scale and marginalized farmers in transitioning to carbon-efficient practices for sustainable agriculture. Overall, it will help to implement the aim of monetizing C credits by the Ministry of Power (catenate notice: CG-DL-E-30062023-246859 Dated June 28, 2023) and the Ministry of Environment, Forests, and Climate Change of Developing (catenate notice: CG-DL-E-27062023-246825 Dated June 27, 2023) and adopted the green credit program. The Indian government has demonstrated its will to combat climate change by starting a policy discussion on carbon. This important conversation aims to establish solutions for sustainable development focusing on environmental stewardship and carbon reduction across several sectors. Ultimately, this would enhance the country's defenses against climate change and encourage net zero emission through C-negative agriculture. It will also promote the �Sustainable Development Goals,� which aim to improve the country and the globe. � 2024 Elsevier Inc.
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    Stabilization of Mine Waste Dumps Through Bio-Engineering
    (Springer, 2024) Chaturvedi A.; Singh G.S.P.; Sharma S.K.
    A continual increase in the quantity of wastes produced make stabilization of waste dumps a formidable task both from economic and technological standpoints. Of late, bio-engineering approach has been emerging as one of the most, affordable, eco-friendly, efficient and widely used methods of stabilizing such waste dumps. This study enumerates various plant species that can be used to reinforce coal mine waste dumps, the factors that affect the choice, and the techniques used to measure their effectiveness as a bio-engineering tool. The outcome of this work can be used for the selection of suitable plant species that would ensure long-term maintenance of the ecosystem as well as mechanical stability of the dumps. Locally available native species that are likely to blend in with the surroundings and adapt quickly to the climate have been suggested for the vegetation of sterile dumps. The Miyawaki plantation approach is recommended as it promotes higher survival, aids in ecological restoration, and improves the mechanical stability of the dump slope. � The Institution of Engineers (India) 2023.
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    Targeting cell cycle regulators: A new paradigm in cancer therapeutics
    (Tech Science Press, 2024) Singh G.; Sharma S.K.; Mishra N.; Soni A.; Kumari M.; Singh S.K.
    Dysregulation of the cell cycle is a molecular hallmark of cancer, which leads to uncontrolled proliferation and self-renewal of neoplastic cells. To maintain this phenotype, cells acquire multiple molecular alterations and bypass several cellular checkpoints that are involved in the prevention of genomic instability and uncontrolled cell proliferation. Therefore, targeting cell cycle regulators could prove to be a promising anti-cancer approach. Recent advancements in the understanding of cancer cell susceptibilities have revealed a therapeutic opportunity to selectively target the cell cycle in malignant cells. This review highlights major cell cycle dysregulation in cancerous cells and the latest developments on anti-cancer agents that target cell cycle factors which are either in clinical practice or in clinical trials at present. In light of increasing drug resistance in cancer patients, the article also discusses mechanistic insights for the exploration of probable therapies that could be used to target these cell cycle factors. Additionally, it outlines the future research necessary to develop new therapies and optimize existing ones to achieve maximum efficacy. Thus, this article aims to provide a comprehensive understanding of the advancements in cancer therapies targeting dysregulated cell cycle factors. Copyright � 2024 The Authors.
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    Unveiling the elemental composition, sources and health impacts of PM10 over the central Indo-Gangetic plain (IGP) of India
    (Elsevier Ltd, 2024) Tiwari P.; Mehrotra B.J.; Gupta S.; Srivastava M.K.; Kumar M.; Vijayan N.; Choudhary A.; Sharma S.K.
    This study investigates the PM10 pollution in the central Indo?Gangetic plain (IGP) of India from February 2018 to December 2019, revealing an annual average PM10 concentration of 193�65 ?g m?�. Seasonal concentrations peaked in winter season followed by summer, post-monsoon and monsoon seasons. WD?XRF identifying 35 elements, including major elements like Si, Al, Ca, and Fe, which contributed 18% to PM10 concentrations. The enrichment factor analysis indicates that the Rb, Sr, and Na originate from natural sources, while Fe, Al, Mn, K, Ca, Mg, and Zr have both natural and anthropogenic sources. The remaining elements are primarily of anthropogenic origin. Source apportionment through Principal Component Analysis (PCA) revealed the six key PM10 sources: mixed type (dust+biomass burning, 42%), vehicular (24%), industrial (15%), combustion (7%), agricultural activities (6%), and fossil fuel combustion (6%). Local sources from the northwest (NW) and west (W) directions were dominant, with smaller contributions from trans-boundary regions like Afghanistan and Pakistan. Health risk assessments highlighted non-carcinogenic risks from Mn for adults and children, with additional risks from Al and Cr for children, and carcinogenic risks from Cr for adults. The risk of Al, Cr and Mn in Varanasi are likely driven by combustion related activities, as Cr and Mn in PM10 are commonly associated with industrial and vehicular emission sources. � 2024 Elsevier Ltd