Browsing by Author "Singh, Amit Kishore"

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    An insight into the molecular docking interactions of plant secondary metabolites with virulent factors causing common human diseases
    (Elsevier B.V., 2022) Kumar, Ajay; Singh, Sandeep Kumar; Singh, Vipin Kumar; Kant, Chandra; Singh, Amit Kishore; Tripathi, Vijay; Singh, Kalpna; Sharma, Vijay Kumar; Singh, Joginder
    Plant natural products or secondary metabolites have gained significant attention globally because of discoveries of semi-synthetic drugs novel bioactive compounds. Currently, a large part of global population relies on natural products to cure ailments and even chronic diseases and to enhance their immune system. Interestingly, the commonly used drugs for the treatment of some common human diseases like cancer, ulcer, tuberculosis, asthma, etc., have been reported to be of plant origin and recognized to elicit beneficial effects in virulent factors of diseases in vivo and in vitro. The herbal drugs are economical and considered as safe upto certain extent from major side effects. But, still there is need of rapid collection, characterization, taxonomy, certification, and storage for broad, efficient and effective use in drug design or discovery. In this review, we summarized the plants derived secondary metabolites used in treating common human diseases and emphasised the protein-ligand interactions between virulent factors of diseases namely Insulin, p53, Proteasome-associated ATPase, Enterotoxin, Choleragen, IgE with secondary metabolites Aloin, Sesamin, Alliin, Flavanon, Salannin Octyl-?-d-Glucopyranoside of plants respectively, through molecular docking. This study will play a valuable and effective role in drug designing and screening plant-derived metabolites for drug designing. � 2021 SAAB
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    Current Scenario and Future Prospects of Endophytic Microbes: Promising Candidates for Abiotic and Biotic Stress Management for Agricultural and Environmental Sustainability
    (Springer, 2023) Anand, Uttpal; Pal, Tarun; Yadav, Niraj; Singh, Vipin Kumar; Tripathi, Vijay; Choudhary, Krishna Kumar; Shukla, Awadhesh Kumar; Sunita, Kumari; Kumar, Ajay; Bontempi, Elza; Ma, Ying; Kolton, Max; Singh, Amit Kishore
    Globally, substantial research into endophytic microbes is being conducted to increase agricultural and environmental sustainability. Endophytic microbes such as bacteria, actinomycetes, and fungi inhabit ubiquitously within the tissues of all plant species without causing any harm or disease. Endophytes form symbiotic relationships with diverse plant species and can regulate numerous host functions, including resistance to abiotic and biotic stresses, growth and development, and stimulating immune systems. Moreover, plant endophytes play a dominant role in nutrient cycling, biodegradation, and bioremediation, and are widely used in many industries. Endophytes have a stronger predisposition for enhancing mineral and metal solubility by cells through the secretion of organic acids with low molecular weight and metal-specific ligands (such as siderophores) that alter soil pH and boost binding activity. Finally, endophytes synthesize various bioactive compounds with high competence that are promising candidates for new drugs, antibiotics, and medicines. Bioprospecting of endophytic novel secondary metabolites has given momentum to sustainable agriculture for combating environmental stresses. Biotechnological interventions with the aid of endophytes played a pivotal role in crop improvement to mitigate biotic and abiotic stress conditions like drought, salinity, xenobiotic compounds, and heavy metals. Identification of putative genes from endophytes conferring resistance and tolerance to crop diseases, apart from those involved in the accumulation and degradation of contaminants, could open new avenues in agricultural research and development. Furthermore, a detailed molecular and biochemical understanding of endophyte entry and colonization strategy in the host would better help in manipulating crop productivity under changing climatic conditions. Therefore, the present review highlights current research trends based on the SCOPUS database, potential biotechnological interventions of endophytic microorganisms in combating environmental stresses influencing crop productivity, future opportunities of endophytes in improving plant stress tolerance, and their contribution to sustainable remediation of hazardous environmental contaminants. Graphical Abstract: [Figure not available: see fulltext.]. � 2023, The Author(s).
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    Potential environmental and human health risks caused by antibiotic-resistant bacteria (ARB), antibiotic resistance genes (ARGs) and emerging contaminants (ECs) from municipal solid waste (MSW) landfill
    (MDPI AG, 2021) Anand, Uttpal; Reddy, Bhaskar; Singh, Vipin Kumar; Singh, Amit Kishore; Kesari, Kavindra Kumar; Tripathi, Pooja; Kumar, Pradeep; Tripathi, Vijay; Simal-Gandara, Jesus
    The disposal of municipal solid waste (MSW) directly at landfills or open dump areas, without segregation and treatment, is a significant concern due to its hazardous contents of antibioticresistant bacteria (ARB), antibiotic resistance genes (ARGs), and metal resistance genes (MGEs). The released leachate from landfills greatly effects the soil physicochemical, biological, and groundwater properties associated with agricultural activity and human health. The abundance of ARB, ARGs, and MGEs have been reported worldwide, including MSW landfill sites, animal husbandry, wastewater, groundwater, soil, and aerosol. This review elucidates the occurrence and abundance of ARB, ARGs, and MRGs, which are regarded as emerging contaminants (ECs). Recently, ECs have received global attention because of their prevalence in leachate as a substantial threat to environmental and public health, including an economic burden for developing nations. The present review exclusively discusses the demands to develop a novel eco-friendly management strategy to combat these global issues. This review also gives an intrinsic discussion about the insights of different aspects of environmental and public health concerns caused due to massive leachate generation, the abundance of antibiotics resistance (AR), and the effects of released leachate on the various environmental reservoirs and human health. Furthermore, the current review throws light on the source and fate of different ECs of landfill leachate and their possible impact on the nearby environments (groundwater, surface water, and soil) affecting human health. The present review strongly suggests the demand for future research focuses on the advancement of the removal efficiency of contaminants with the improvement of relevant landfill management to reduce the potential effects of disposable waste. We propose the necessity of the identification and monitoring of potential environmental and human health risks associated with landfill leachate contaminants. � 2021 by the authors.