Browsing by Author "Srivastava N.K."
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Item A comprehensive expedition of tauopathies in subacute sclerosing panencephalitis (SSPE): a narrative review(Springer Science and Business Media Deutschland GmbH, 2024) Pandey N.; Srivastava N.K.; Kumar A.; Hussain I.; Joshi D.Introduction: Tauopathies are a class of neurodegenerative disorders characterized by the abnormal accumulation of hyperphosphorylated tau protein in the brain. Subacute sclerosing panencephalitis (SSPE) caused by a latent aberrant measles virus infection, is characterized by extensive inflammation and neuronal impairment. A prominent pathological hallmark of SSPE described recently is the accumulation of abnormal tau protein possibly resulting from diffuse brain inflammation triggered by measles virus infection. Short summary: Understanding the role of tau pathophysiology in SSPE is crucial for improving the diagnosis and management of this debilitating condition. Current research suggests that persistent measles virus infection in the brain leads to chronic inflammation, which in turn triggers abnormal tau phosphorylation and accumulation. Further elucidating the precise mechanisms linking measles virus infection, neuro-inflammation, and tauopathy in SSPE is essential for developing targeted therapies. Conclusion: This narrative review provides valuable insights for both researchers and clinicians in understanding the pathological mechanisms underlying SSPE which is crucial for developing effective treatment strategies. These might include antiviral drugs to combat persistent infection, anti-inflammatory agents to reduce neuro-inflammation, or even treatments targeting tau pathology directly. Collaborative efforts among researchers, clinicians, and public health authorities are crucial for advancing our understanding of SSPE to combat this devastating disorder. � The Author(s) 2024.Item Cumulative influence of immunogenic factors, genetic variations, and protein modulations in subacute sclerosing panencephalitis (SSPE): A narrative review(John Wiley and Sons Inc, 2024) Pandey N.; Srivastava N.K.; Kumar A.; Hussain I.; Joshi D.Subacute sclerosing panencephalitis (SSPE) is a progressive and catastrophic neurodegenerative disorder due to persistent infection with the aberrant measles virus in the brain. The exact etiology of SSPE is still unknown, and early diagnosis remains a challenge, especially with the atypical presentations. The pathogenesis of SSPE involves a complex interplay between viral factors and immunological response of the host. The presenting review demonstrates an extensive glimpse of the immuno-genetics of SSPE, exploring the single-nucleotide polymorphisms (SNPs), genetic risk factors and immune responses that influence susceptibility and disease progression. � 2024 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd.