Browsing by Author "Tripathi A.K."

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    Biosynthesis of carotenoids in Azospirillum brasilense Cd is mediated via squalene (C30) route
    (Elsevier B.V., 2024) Tiwari N.; Tripathi A.K.
    Azospirillum brasilense is a non-photosynthetic ?-Proteobacteria, belongs to the family of Rhodospirillaceae and produces carotenoids to protect itself from photooxidative stress. In this study, we have used Resonance Raman Spectra to show similarity of bacterioruberins of Halobacterium salinarum to that of A. brasilense Cd. To navigate the role of genes involved in carotenoid biosynthesis, we used mutational analysis to inactivate putative genes predicted to be involved in carotenoid biosynthesis in A. brasilense Cd. We have shown that HpnCED enzymes are involved in the biosynthesis of squalene (C30), which is required for the synthesis of carotenoids in A. brasilense Cd. We also found that CrtI and CrtP desaturases were involved in the transformation of colorless squalene into the pink-pigmented carotenoids. This study elucidates role of some genes which constitute very pivotal role in biosynthetic pathway of carotenoid in A. brasilense Cd. � 2024 Elsevier Inc.
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    Correction to: PLGA-Quercetin Nano-Formulation Inhibits Cancer Progression via Mitochondrial Dependent Caspase-3,7 and Independent FoxO1 Activation with Concomitant PI3K/AKT Suppression (Pharmaceutics, (2022), 14, 7, (1326), 10.3390/pharmaceutics14071326)
    (Multidisciplinary Digital Publishing Institute (MDPI), 2024) Yadav N.; Tripathi A.K.; Parveen A.; Parveen S.; Banerjee M.
    In the published publication [1], there was an error regarding the affiliation for Neera Yadav. In addition to affiliation 1, the updated affiliation should include: Molecular and Human Genetics Lab, Department of Zoology, University of Lucknow, Lucknow 226007, India. Neera Yadav did not act as the corresponding author any more. Shama Parveen and Monisha Banerjee (the corresponding author) were not included as authors in the original publication [1]. The corrected Author Contributions statement appears here. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated. Shama Parveen: investigation, formal analysis, methodology; Monisha Banerjee: project administration, funding acquisition, resources, supervision, writing�review and editing. The authors also acknowledge Ratan Singh Ray, CSIR-Indian Institute of Toxicology Research (IITR), Lucknow, India, for the synthesis of nanoparticles; Birbal Sahni Institute of Palaeosciences (BSIP), Lucknow, for the SEM facility; Centre of Excellence, Higher Education Government of Uttar Pradesh for the cell culture facility at the Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow-226007, India. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor and Editor-in-Chief. The original publication has also been updated. � 2024 by the authors.
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    In silico and�network pharmacology�analysis of fucosterol: a potent anticancer bioactive compound against HCC
    (Springer, 2024) Singh K.; Kumar P.; Singh A.K.; Singh N.; Singh S.; Tiwari K.N.; Agrawal S.; Das R.; Singh A.; Ram B.; Tripathi A.K.; Mishra S.K.
    The Fucaceae family of marine brown algae includes Ascophyllum nodosum. Fucosterol (FSL) is a unique bioactive component that was identified through GC-MS analysis of the hydroalcoholic extract of A. nodosum. Fucosterol's mechanism of action towards hepatocellular cancer was clarified using network pharmacology and docking study techniques. The probable target gene of FSL has been predicted using the TargetNet and SwissTargetPred databases. GeneCards and the DisGNet database were used to check the targeted genes of FSL. By using the web programme Venny 2.1, the overlaps of FSL and HCC disease demonstrated that 18 genes (1.3%) were obtained as targeted genes Via the STRING database, a protein�protein interaction (PPI) network with 18 common target genes was constructed. With the aid of CytoNCA, hub genes were screened using the Cytoscape software, and the targets' hub genes were exported into the ShinyGo online tool for study of KEGG and gene ontology enrichment. Using the software AutoDock, a hub gene molecular docking study was performed. Ten genes, including AR, CYP19A1, ESR1, ESR2, TNF, PPARA, PPARG, HMGCR, SRC, and IGF1R, were obtained. The 10 targeted hubs docked with FSL successfully. The active components FSL of ASD, the FSL, are engaged in fatty liver disease, cancer pathways, and other signalling pathways, which could prove beneficial for the management of HCC. � The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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    Influence of La3+ doping on structural and optical properties of SrCeO3 perovskite
    (Institute of Physics, 2024) Yadav D.; Kumar P.; Tripathi A.K.; Yadav R.S.; Nirala G.; Yadav S.; Yadav A.K.; Yadav S.
    The SrCe1-xLaxO3 (x = 0.0, 0.02, 0.4, 0.6, and 0.10) perovskite materials have been successfully synthesized by auto-combustion method and calcined at 1100�C. The XRD patterns reveal a highly crystalline orthorhombic crystal structure with a Pnma space group in all samples. The TEM micrograph shows a spherical morphology of the 10 mol% La3+ doped SrCeO3 perovskite sample alongwith the SAED pattern confirming its highly crystalline nature. The incorporation of La3+ ion in the SrCeO3 perovskite has been confirmed by the Raman and Fourier transform infrared (FTIR) measurements. The UV-vis absorption spectra at room temperature show various bands, with a strong absorption band observed below 400 nm. The optical band gap of the undoped and La3+ doped samples have been calculated and it is smaller for the La3+ doped perovskite samples than that of the undoped perovskite sample. Therefore, the La3+ doped SrCeO3 perovskite may be applicable for optoelectronic applications. � 2024 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.