Browsing by Author "Yadav, Lokesh Kumar"

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    A Multi-Objective Approach for Voltage Stability Enhancement and Loss Reduction under PQV and P Buses Through Reconfiguration and Distributed Generation Allocation
    (Institute of Electrical and Electronics Engineers Inc., 2022) Barnwal, Akhilesh Kumar; Yadav, Lokesh Kumar; Verma, Mitresh Kumar
    This paper proposes a novel approach of voltage stability enhancement and power loss minimization in addition to maintenance of good voltage profile in radial distribution networks through optimally placed distributed generation, network reconfiguration and voltage control of PQV bus through variable reactive power source at P bus. A multi-objective function has been proposed that considers maximum system loadability enhancement and network loss minimization. Optimization of proposed multi-objective function, under distributed generation and network reconfiguration with presence of PQV and P buses in the system have been done using grey wolf optimization technique. Case studies performed on IEEE 33-bus radial distribution system shows that presence of PQV and P buses in the system yields significant enhancement in voltage stability margin under optimal placement of distributed generations and network reconfiguration. � 2013 IEEE.
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    Potential implications of protein kinase C? in pathophysiological conditions and therapeutic interventions
    (Elsevier Inc., 2023) Singh, Rishi Kant; Kumar, Sanjay; Kumar, Sandeep; Shukla, Alok; Kumar, Naveen; Patel, Anand Kumar; Yadav, Lokesh Kumar; Kaushalendra; Antiwal, Meera; Acharya, Arbind
    PKC? is a molecule with many functions that play an important role in cell survival and death to maintain cellular homeostasis. Alteration in the normal functioning of PKC? is responsible for the complicated etiology of many pathologies, including cancer, cardiovascular diseases, kidney complications, neurodegenerative diseases, diabetics, and many others. Several studies have been carried out over the years on this kinase's function, and regulation in normal physiology and pathological conditions. A lot of data with antithetical results have therefore accumulated over time to create a complex framework of physiological implications connected to the PKC? function that needs comprehensive elucidation. In light of this information, we critically analyze the multiple roles played by PKC? in basic cellular processes and their molecular mechanism during various pathological conditions. This review further discusses the current approaches to manipulating PKC? signaling amplitude in the patient's favour and proposed PKC? as a therapeutic target to reverse pathological states. � 2023 Elsevier Inc.