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Curcumin: a spice pigment against hepatic cancer

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dc.contributor.authorSoni, Vivek Kumar
dc.contributor.authorRatre, Yashwant Kumar
dc.contributor.authorMehta, Arundhati
dc.contributor.authorDixit, Ashwini Kumar
dc.contributor.authorDwivedi, Mrigendra
dc.contributor.authorShukla, Dhananjay
dc.contributor.authorKumar, Ajay
dc.contributor.authorVishvakarma, Naveen Kumar
dc.date.accessioned2025-01-27T10:13:34Z
dc.date.available2025-01-27T10:13:34Z
dc.date.issued2022
dc.description.abstractHepatic cancer is one of the most deadly malignancies owing to the pivotal role of liver in physiological homeostasis. Various strategies are being implemented to combat the onset and progression of liver cancer that has achieved promising success. However, conventional therapeutic approaches have their own limitations, particularly nonspecific toxicity and the onset of the chemoresistance. Therefore alternative approaches, including bioactive components of natural origins are being explored for their antineoplastic activity. Curcumin, the yellow pigment of turmeric spice, has shown effective cytotoxic activity against numerous malignant cells, including hepatic cancer. The abilities of curcumin such as its antioxidant nature, antiinflammatory effects, immunostimulatory activity, and protective behavior against organ damage make this phytochemical as a better choice of therapeutic agent in various medical ailments including malignancies of hepatic origin. Mechanistic explorations on curcumin have identified various molecular targets for its therapeutic effects against liver cancer. Moreover, curcumin is devoid of any specific adverse effects and safe for consumption. Curcumin also exhibits chemosensitizing ability and makes liver cancer cells more susceptible to conventional chemotherapeutic drugs. Although few concerns, including bioavailability and its metabolism limit the optimal clinical exploitation of curcumin, its derivatives is found to overcome such obstacles. Collectively curcumin stands high in prospective therapeutic molecules against liver cancers with evident success in preclinical as well clinical investigations. � 2022 Elsevier Inc. All rights reserved.
dc.identifier.doihttps://doi.org/10.1016/B978-0-323-99283-1.00007-0
dc.identifier.isbn978-032399283-1; 978-032399284-8
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/14556
dc.publisherElsevier
dc.subjectanalogs
dc.subjectchemosensitization
dc.subjectCurcumin
dc.subjectimmunomodulation
dc.subjectliver cancer
dc.titleCurcumin: a spice pigment against hepatic cancer
dc.typeBook chapter
dspace.entity.typePublication
journal.titleTheranostics and Precision Medicine for the Management of Hepatocellular Carcinoma: Volume 3: Translational and Clinical Outcomes

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