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Role of IL-1 gene polymorphisms in common solid cancers

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dc.contributor.authorSingh, Ragini D.
dc.contributor.authorDholariya, Sagar
dc.contributor.authorShekher, Anusmita
dc.contributor.authorAvadhesh
dc.contributor.authorParchwani, Deepak
dc.contributor.authorGupta, Subash C.
dc.date.accessioned2025-01-28T10:04:29Z
dc.date.available2025-01-28T10:04:29Z
dc.date.issued2023
dc.description.abstractBecause of the strong association of inflammation with cancer, the master cytokine, interleukin-1 (IL-1), has been extensively researched for its role in carcinogenesis. An appropriate, limited, targeted inflammatory response may provide protection to the host. However, on the other hand, an unusually protracted or severe inflammatory response may generate a microenvironment conducive to carcinogenesis. Inherited variants in the IL-1 gene affect its expression and eventually the molecular physiology of the IL-1 system. Studies have reported a wide variety of genetic variations inside the IL-1 gene cluster. Also, interpopulation differences in the distribution of polymorphic IL-1 genotypes are widespread. The polymorphic forms exert effects on cancer risk, development, and progression. This chapter focuses on the structure of the IL-1 gene, the polymorphisms reported in the IL-1 prototypes, i.e., IL1A, IL1B, and IL1RN, and the current knowledge on the involvement of polymorphic forms of IL-1 prototypes in cancer predisposition and prognosis, with particular emphasis on solid tumors. � 2023 Elsevier Inc. All rights reserved.
dc.identifier.doihttps://doi.org/10.1016/B978-0-12-824273-5.00002-7
dc.identifier.isbn978-012824273-5; 978-032385967-7
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/23465
dc.language.isoen
dc.publisherElsevier
dc.subjectCancer
dc.subjectCytokines
dc.subjectInflammation
dc.subjectInterleukin
dc.subjectPolymorphism
dc.titleRole of IL-1 gene polymorphisms in common solid cancers
dc.typeBook chapter
dspace.entity.typePublication
journal.titleMultifaceted Role of IL-1 in Cancer and Inflammation

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