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COVID-19-associated Mucormycosis: A clinico-epidemiological study

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dc.contributor.authorChakravarty, Jaya
dc.contributor.authorGupta, Munesh Kumar
dc.contributor.authorTilak, Ragini
dc.contributor.authorkumar, Rajesh
dc.contributor.authorMaurya, Rajendra Prakash
dc.contributor.authorKumar, Nilesh
dc.contributor.authorAggarwal, Susheel Kumar
dc.contributor.authorS, Shiva
dc.contributor.authorSharma, Naresh Kumar
dc.contributor.authorDhiman, Neeraj Kumar
dc.contributor.authorchaubey, Manaswi
dc.contributor.authorSingh, Vishambhar
dc.contributor.authorverma, Ashish
dc.contributor.authorBanerjee, Tuhina
dc.contributor.authorAgrawal, Neeraj Kumar
dc.contributor.authorPrasad, Ravi Shankar
dc.date.accessioned2025-02-28T10:58:59Z
dc.date.available2025-02-28T10:58:59Z
dc.date.issued2022
dc.description.abstractBackground: There was an unprecedented increase in COVID-19-associated-Mucormycosis (CAM) cases during the second pandemic wave in India. Methods: This observational study was done to know the epidemiological profile of CAM cases andincluded all patients admitted with mucormycosis between May 2021 and July 2021. Results: Out of the enrolled 208 CAM cases (either SARS-CoV-2 RT-PCR or serology positive), 204, three and one had rhino-orbital-cerebral, pulmonary and gastrointestinal mucormycosis, respectively. 95.7 % of the patients had diabetes, out of which 42.3 % were recently diagnosed. Mean HbA1c was 10.16 ± 2.56 %. 82.5 % of the patients were unvaccinated. During their COVID-19 illness, 86.5 % were prescribed antibiotics, 84.6 % zinc preparations, 76.4 % ivermectin, and 64.9 % steroids, while only 39.5 % required oxygen therapy. The frequency of blood groups A, B, O and AB in our CAM patients was 29.5 %, 18.9 %, 38.9 % &12.6 %, respectively. At three months follow up, 60 (28.8 %) patients died, four (1.9 %) stopped antifungal treatment, and 144(69.23 %) were on antifungal treatment. 55 % (n = 33) of deaths occurred within 15 days of admission. Mortality was significantly associated with higher age, RT-PCR positive for SARS-CoV-2, raised serum creatinine and alkaline phosphatase during treatment. At 6 months follow-up, eight more patients died, three due to chronic kidney disease, four patients who had stopped treatment and one patient who was on a ventilator due to COVID-19 associated pneumonia and the rest 140(67.3 %) survived. Conclusion: Uncontrolled hyperglycemia, SARS-CoV-2 infection, rampant use of antibiotics, zinc supplementation and steroids were some of the risk factors for mucormycosis. Despite the overwhelming number of patients with an uncommon disease like mucormycosis, the six months mortality was much lower than expected. © 2022
dc.identifier.doihttps://doi.org/10.1016/j.jdiacomp.2022.108284
dc.identifier.issn10568727
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/62446
dc.publisherElsevier Inc.
dc.subjectCOVID-19
dc.subjectDiabetes
dc.subjectMucormycosis
dc.subjectPosaconazole
dc.subjectSteroid
dc.subjectZinc
dc.titleCOVID-19-associated Mucormycosis: A clinico-epidemiological study
dc.typeArticle
dspace.entity.typePublication
journal.titleJournal of Diabetes and its Complications
journalvolume.identifier.volume36

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