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Electrochemical sensor for uric acid based on a molecularly imprinted polymer brush grafted to tetraethoxysilane derived sol-gel thin film graphite electrode

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dc.contributor.authorPatel, A.K.
dc.contributor.authorSharma, P.S.
dc.contributor.authorPrasad, B.B.
dc.date.accessioned2025-03-03T10:26:15Z
dc.date.available2025-03-03T10:26:15Z
dc.date.issued2009
dc.description.abstractDetermination of uric acid in human serum and urine is useful to provide treatment guidelines to hyperuricemic patients. An electrochemical sensor was developed for selective and quantitative recognition of uric acid by using a preanodised sol-gel coated graphite electrode with a molecularly imprinted polymer brush of poly(melamine-co-chloranil) grafted to its exterior surface. During a preconcentration step at (+ 2.0 V versus saturated calomel electrode), the encapsulated analyte recapture involved hydrophobically induced hydrogen-bondings in outwardly exposed MIP cavities in aqueous environment (pH 7.0), instantly oxidised as dications, and then cathodically stripped off as corresponding lactam responding differential pulse, cathodic stripping voltammetric signal. The uric acid was selectively detected without any cross reactivity in the windows of 14.56-177.42 μg mL- 1 (aqueous medium), 4.78-106.96 μg mL- 1 (blood serum), and 7.81-148.42 μg mL- 1 (urine) indicating detection limits in the range of 3.71-4.10 μg mL- 1 (3σ, RSD = 1.9%). © 2008 Elsevier B.V. All rights reserved.
dc.identifier.doihttps://doi.org/10.1016/j.msec.2008.12.008
dc.identifier.issn9284931
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/82812
dc.subjectCathodic stripping voltammetry
dc.subjectDifferential pulse
dc.subjectGraphite electrode
dc.subjectMolecularly imprinted polymer brush
dc.subjectSol-gel
dc.subjectUric acid sensor
dc.titleElectrochemical sensor for uric acid based on a molecularly imprinted polymer brush grafted to tetraethoxysilane derived sol-gel thin film graphite electrode
dc.typeArticle
dspace.entity.typePublication
journal.titleMaterials Science and Engineering C
journalvolume.identifier.volume29

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2009