Publication: Genetic Association in Lower Limb Swelling
| dc.contributor.author | Rai, Geeta | |
| dc.contributor.author | Priya, Khushbu | |
| dc.contributor.author | Das, Doli | |
| dc.date.accessioned | 2025-01-27T10:13:17Z | |
| dc.date.available | 2025-01-27T10:13:17Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Leg swelling or edema involves a wide spectrum of causes and symptoms. They can be diagnosed by classifying them on the basis of different parameters like duration of disease-swelling is acute or chronic, the distribution of swelling-whether it involves one leg (unilateral), both the legs (bilateral), or either of them (unilateral or bilateral), and the associated symptoms such as dyspnea, pain, thickening of skin, and pigmentation. Systemic diseases such as heart failure, liver disease, thyroid disorder and local conditions such as pelvic tumors, infection, trauma, and venous thrombosis are the different diagnosis associated with the risk of lower limb edema. There is robust conditional evidence which implicates genetics in the etiology and pathology of this disease. With the inadequate knowledge of the biological pathways concerned with the pathogenesis of venous disease, it is difficult to devise erudite candidate gene hypothesis-directed studies. Hence, the study of associated genes and proteins should be considered to help enhance the current understanding of the inheritance of disease, and also, they can serve as good candidates for follow-up functional studies and be significant as potential drug targets. The knowledge of genetics and genomics associated with a condition would help physicians in the treatment of the progressive disease. � The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022. | |
| dc.identifier.doi | https://doi.org/10.1007/978-981-16-6206-5_14 | |
| dc.identifier.isbn | 978-981166206-5; 978-981166205-8 | |
| dc.identifier.uri | https://dl.bhu.ac.in/ir/handle/123456789/14528 | |
| dc.publisher | Springer Nature | |
| dc.subject | Edema | |
| dc.subject | Genetics | |
| dc.subject | Leg swelling | |
| dc.subject | Lower extremity | |
| dc.title | Genetic Association in Lower Limb Swelling | |
| dc.type | Book chapter | |
| dspace.entity.type | Publication | |
| journal.title | Approach to Lower Limb Oedema |