Publication: Green synthesis, characterization and in vitro biological studies of quercetin complexes with Zn (II) acetate and N^N Moiety
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Date
2021
Journal Title
Research Journal of Pharmacy and Technology
Journal ISSN
Volume Title
Publisher
Research Journal of Pharmacy and Technology
Abstract
Green synthesis of two coordination complexes of zinc acetate with N^N moiety on quercetin, which is a flavonoid is carried out. The complexes were obtained in high yields (> 97%) by grinding methods without the involvement of any solvent. Neither catalyst nor any additives were needed to perform the reactions. It was characterized by FT-IR, UV-Vis, NMR, HRMS, and elemental analysis. Antioxidant activity was done through the DPPH method which was compared with ascorbic acid and ligand (Quercetin). The study reveals that Complex 1 (IC50 163.093�g/ml) has significant free radical scavenging activity as compared to complex 2 (IC50 258.683�g/ml). Biological activity was performed against microbes (E. coli and S. aureus). MIC value of complex 1 (15.50�g/ml E. coli, 7.18�g/ml S. aureus) was found more significant as compared to complex 2 (22.51�g/ml E. coli, 18.62�g/ml S. aureus) and quercetin. � RJPT All right reserved.
Description
Keywords
Coordination complexes, DPPH, Minimum inhibitory concentration, Solid-state