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Lysozyme levels for the diagnosis of tuberculous effusions in children

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dc.contributor.authorMishra, O.P.
dc.contributor.authorYusuf, S.
dc.contributor.authorAli, Z.
dc.contributor.authorNath, G.
dc.date.accessioned2025-03-04T07:22:45Z
dc.date.available2025-03-04T07:22:45Z
dc.date.issued2000
dc.description.abstractLysozyme level was measured in the fluid and serum of 42 tuberculous (25 pleural, 11 ascites and 6 pericardial) and 29 non-tuberculous (5 malignant, 9 empyema thoracis, 10 transudative ascites and 5 pyopericardium) effusions. The mean fluid lysozyme level was significantly raised in tuberculous pleural, ascites, and pericardial effusions in comparison to malignant pleural (p< 0.001), transudative ascites (p < 0.001), and pyopericardium (p < 0.02) cases, respectively. The mean fluid/serum lysozyme ratio did not differ significantly between tuberculous and their corresponding non-tuberculous effusions. The confirmed tuberculous pleural effusion patients had significantly higher mean fluid lysozyme level and fluid/serum lysozyme ratio when compared with clinical cases (p < 0.05). The cut-off fluid lysozyme level of ≥50/UI-1 and fluid/serum lysozyme ratio of ≥1.1 were considered for the diagnosis of tuberculous effusions; the sensitivity and specificity of fluid lysozyme and fluid/serum lysozyme ratios were 100, 100 per cent, and 97.6, 33.3 per cent, respectively, on excluding the patients with purulent effusions. A significant correlation was observed between the fluid and serum lysozyme levels in tuberculous effusions (r = 0.39, p < 0.01). Thus, fluid lysozyme was found to be a better and reliable test than fluid/serum lysozyme ratio for the diagnosis of tuberculous effusions in children.
dc.identifier.doihttps://doi.org/10.1093/tropej/46.5.296
dc.identifier.issn1426338
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/89505
dc.publisherOxford University Press
dc.titleLysozyme levels for the diagnosis of tuberculous effusions in children
dc.typeArticle
dspace.entity.typePublication
journal.titleJournal of Tropical Pediatrics
journalvolume.identifier.volume46

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