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CXCL12 is a key regulator in tumor microenvironment of cervical cancer: an in vitro study

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dc.contributor.authorYadav, Suresh Singh
dc.contributor.authorPrasad, Shyam Babu
dc.contributor.authorPrasad, Chandra Bhushan
dc.contributor.authorPandey, Lakshmi Kant
dc.contributor.authorPradhan, Satyajit
dc.contributor.authorSingh, Sunita
dc.contributor.authorNarayan, Gopeshwar
dc.date.accessioned2025-03-01T11:01:38Z
dc.date.available2025-03-01T11:01:38Z
dc.date.issued2016
dc.description.abstractCXCL12 is a small pro-inflammatory chemo-attractant cytokine which signals through chemokine receptor CXCR4. The importance of CXCL12/CXCR4 axis is coming to the fore in several divergent signaling pathway-initiating signals related to cell survival and/or proliferation and cancer metastasis. In the present study we have investigated whether deregulation in CXCR4 signaling (as a consequence of deregulated expression of CXCL12) modulate the metastatic potential of cervical carcinoma cells. We demonstrate that CXCL12 is frequently down regulated and its promoter is hypermethylated in cervical cancer cell lines and primary tumor biopsies. Exogenous treatment of cervical cancer cell lines (HeLa, SiHa and C-33A) with recombinant CXCL12 inhibited the metastasis promoting cell migration, cell invasion and anchorage independent cell growth events. Although this study will need further in vivo validation, our observations suggest that (a) silencing of CXCL12 in cervical cancer cells may be critical in migration and invasion, the key events in cancer cell metastases; (b) cervical cancer cells having down regulated CXCL12 are more prone to being attracted to CXCL12 expressed at secondary sites of metastases; and (c) CXCL12 inhibits anchorage independent cell growth via anoikis. These findings suggest the tumor suppressor functions of CXCL12 in cervical cancer. © 2016, Springer Science+Business Media Dordrecht.
dc.identifier.doihttps://doi.org/10.1007/s10585-016-9787-9
dc.identifier.issn2620898
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/74302
dc.publisherSpringer Netherlands
dc.subjectAnchorage independent cell growth
dc.subjectCell invasion
dc.subjectCell migration
dc.subjectCervical cancer
dc.subjectCXCL12
dc.subjectPromoter hypermethylation
dc.titleCXCL12 is a key regulator in tumor microenvironment of cervical cancer: an in vitro study
dc.typeArticle
dspace.entity.typePublication
journal.titleClinical and Experimental Metastasis
journalvolume.identifier.volume33

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2016