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A comparative study of clinical effects and recovery characteristics of intraoperative dexmedetomidine infusion with ketamine versus fentanyl as adjuvants in general anaesthesia

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dc.contributor.authorLodhi, Mehershre
dc.contributor.authorSulakshana, Sulakshana
dc.contributor.authorSingh, Anil P.
dc.contributor.authorGupta, Bikram K.
dc.date.accessioned2025-01-28T09:53:15Z
dc.date.available2025-01-28T09:53:15Z
dc.date.issued2023
dc.description.abstractBackground and Aims: Intraoperative dexmedetomidine infusion decreases the concurrent anaesthetic and analgesic requirement. However, because of slow onset and offset, it is often used with other drugs. Opioids have a depressant effect on the cardiorespiratory system while ketamine has the opposite pharmacodynamics. Hence, it was hypothesised that ketamine will have a better intraoperative haemodynamic profile compared to fentanyl. This study compared the clinical effects and recovery characteristics of ketamine versus fentanyl when used as an adjuvant along with dexmedetomidine infusion intraoperatively. Methods: A total of 80 patients (18-60 years) undergoing major surgeries were divided into two groups: Group (D + K) received an intraoperative infusion of ketamine 0.5 mg/kg/h, while group (D + F) received fentanyl 0.5 ?g/kg/h along with intravenous dexmedetomidine 0.5 ?g/kg/h. Intraoperative heart rate (HR), mean blood pressure, and oxygen saturation were recorded at 0 min, 10 min of induction, and thereafter every 30 min throughout the procedure. Ramsay sedation score (RSS) and visual analogue scale (VAS) score were measured at the end of the surgery, at 2 hours, 4 hours, and 6 hours. Results: Reduction in HR and mean blood pressure was more with a tendency of developing hypotension in the fentanyl group compared to the ketamine group. Post-Anaesthesia care unit (PACU) stay, need for muscle relaxant and VAS score for pain were also significantly lesser in the ketamine group. Conclusion: Dexmedetomidine with ketamine provided better haemodynamic stability and reduced PACU stay compared to dexmedetomidine with fentanyl. � 2023 Wolters Kluwer Medknow Publications. All rights reserved.
dc.identifier.doihttps://doi.org/10.4103/ija.ija_294_22
dc.identifier.issn195049
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/22754
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.subjectAnalgesia
dc.subjectdexmedetomidine
dc.subjectfentanyl
dc.subjectketamine
dc.subjectsedation
dc.titleA comparative study of clinical effects and recovery characteristics of intraoperative dexmedetomidine infusion with ketamine versus fentanyl as adjuvants in general anaesthesia
dc.typeArticle
dspace.entity.typePublication
journal.titleIndian Journal of Anaesthesia
journalvolume.identifier.volume67

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2023