Publication: Pregabalin Induced Maculopapular Eruption in an Elderly Male
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Date
2022
Journal Title
Current Drug Safety
Journal ISSN
Volume Title
Publisher
Bentham Science Publishers
Abstract
Background: Pregabalin is used in the treatment of neuropathic pain of various etiolo-gies and as an adjuvant in epilepsy. Blockade of the ?2? subunit of L and N-type Ca-channels is its main mechanism of neurotropic action. Compared to other antiepileptics like phenytoin, valproate and lamotrigine, and other neuropathic pain medications such as amitriptyline and duloxetine, pregabalin has a relatively favorable safety profile and hence is a drug of choice for many geriatri-cians. Case Presentation: Here we describe a case of maculopapular rash induced by pregabalin in an older man, which resolved with withdrawal of the offending drug and conservative management. Conclusion: We have also conducted a literature review of similar cases and highlighted the clinical patterns and management strategies for pregabalin-induced skin rashes. � 2022 Bentham Science Publishers.
Description
Keywords
Anticonvulsant, dermatology, idiosyncratic, Pregabalin, rash, skin