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Efficacy of Cinnamomum cassia essential oil against food-borne molds and aflatoxin B1 contamination

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dc.contributor.authorSingh, Akanksha
dc.contributor.authorDeepika
dc.contributor.authorChaudhari, Anand Kumar
dc.contributor.authorDas, Somenath
dc.contributor.authorPrasad, Jitendra
dc.contributor.authorDwivedy, Abhishek Kumar
dc.contributor.authorDubey, Nawal Kishore
dc.date.accessioned2025-01-30T06:17:57Z
dc.date.available2025-01-30T06:17:57Z
dc.date.issued2021
dc.description.abstractThe present study deals with the antifungal and antiaflatoxigenic potential of Cinnamomum cassia essential oil (CCEO) against aflatoxigenic food borne Aspergillus flavus strain (AF-LHP-PE-4), and probable mode of action including the safety profile on male mice. CCEO completely inhibited fungal growth and aflatoxin B1 secretion at its minimum inhibitory concentration (0.06 �L/mL). CCEO inhibited ergosterol biosynthesis in cell membranes and also disturbed the membrane fluidity. Significant enhancement in leakage of cellular ions and 260 and 280 nm absorbing cellular materials in response to increased concentrations of CCEO indicated the plasma membrane as the probable site of antifungal toxicity. The antiaflatoxigenic potency of CCEO was confirmed in terms of reduction in the level of cellular methylglyoxal (MG), the inducer of aflatoxin. Antioxidant activity of CCEO was confirmed through DPPH free radical scavenging activity as well as total phenolic content. Chemical profiling of CCEO by gas chromatography-mass spectrometry (GC-MS) analysis revealed the presence of cinnamaldehyde (84.01%) as the most abundant compound. CCEO exhibited a high LD50 (10410.75 �L/kg) on male mice, strengthening its favorable safety profile. This is the first report on CCEO as novel green preservative against food storage molds and aflatoxin B1 secretion. � 2020 Societ� Botanica Italiana.
dc.identifier.doihttps://doi.org/10.1080/11263504.2020.1810804
dc.identifier.issn11263504
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/26260
dc.publisherTaylor and Francis Ltd.
dc.subjectaflatoxin B<sub>1</sub>
dc.subjectcinnamaldehyde
dc.subjectCinnamomum cassia essential oil
dc.subjectfood-borne molds
dc.subjectgreen preservative
dc.subjectmethylglyoxal
dc.subjectsafety profile
dc.titleEfficacy of Cinnamomum cassia essential oil against food-borne molds and aflatoxin B1 contamination
dc.typeArticle
dspace.entity.typePublication
journal.titlePlant Biosystems
journalvolume.identifier.volume155

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2021