Publication: Organocatalyzed epoxidation in the total synthesis of (?)-trans-, (+)-trans- and (+)-cis-disparlures
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Date
2023
Authors
Journal Title
Organic and Biomolecular Chemistry
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
A simple, flexible and efficient organocatalyzed synthetic approach for the synthesis of (?)-trans-, (+)-trans- and (+)-cis-disparlures has been described. The pivotal reaction sequence comprises organocatalyzed asymmetric J�rgensen epoxidation, Wittig olefination, migration of epoxide and Mitsunobu inversion reaction. Excellent enantiomeric purity (?99%) was achieved during the synthesis of disparlure enantiomers by the J�rgensen epoxidation key step. � 2023 The Royal Society of Chemistry.