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A dihydrazone based “turn–on” fluorescent probe for selective determination of Al3+ ions in aqueous ethanol

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dc.contributor.authorSingh, Divya Pratap
dc.contributor.authorDwivedi, Romi
dc.contributor.authorSingh, Ashish Kumar
dc.contributor.authorKoch, Biplob
dc.contributor.authorSingh, Priya
dc.contributor.authorSingh, Vinod Prasad
dc.date.accessioned2025-03-01T10:45:48Z
dc.date.available2025-03-01T10:45:48Z
dc.date.issued2017
dc.description.abstractAn efficient and highly selective dihydrazone based fluorescent probe N′,N′–bis((2–hydroxynaphthalen–1–yl)methylene)malonohydrazide (H2nmh), has been synthesized for selective detection of Al3+ ions and characterized by different physico–chemical and spectroscopic techniques. The probe shows an enhanced fluorescence in the presence of Al3+ ions in ethanol–water (2:3 v/v) solution which is not observed in the presence of other cations (Na+, K+, Mg2+, Ca2+, Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, Pb2+, Cd2+ and Hg2+). The binding modes of H2nmh with Al3+ were studied by UV–vis, fluorescence and 1H NMR titrations. The probe act as dibasic hexa–dentate ligand and interacts with two Al3+ ions with a binding constant KB = 5.74 × 109 M−1 and detection limit 5.78 × 10−8 M. Detailed insights of probe–metal interaction mechanism were studied by mean of density functional theory (DFT) as well as time dependent–DFT calculation. MTT assay on live MCF–7 cells has been performed to evaluate the cytotoxicity of the probe which suggests viability of the probe to MCF–7 cells even at higher concentration (100 μM) with no serious cytotoxicity in cells. Live cell imaging study clearly indicates that the accumulation of Al3+ in the cytoplasm of cells can be detected by H2nmh. © 2016 Elsevier B.V.
dc.identifier.doihttps://doi.org/10.1016/j.snb.2016.07.043
dc.identifier.issn9254005
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/73569
dc.publisherElsevier B.V.
dc.subject<sup>1</sup>H NMR titration
dc.subjectAcyldihydrazone
dc.subjectBinding constant
dc.subjectCell imaging
dc.subjectDetection limit
dc.subjectFluorescent probe
dc.titleA dihydrazone based “turn–on” fluorescent probe for selective determination of Al3+ ions in aqueous ethanol
dc.typeArticle
dspace.entity.typePublication
journal.titleSensors and Actuators, B: Chemical
journalvolume.identifier.volume238

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2017