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7-Azaspiroketal as a unique and effective auxochrome moiety: demonstration in a fluorescent coumarin dye and application in cell imaging

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dc.contributor.authorIndurthi, Harish K.
dc.contributor.authorGoswami, Pooja
dc.contributor.authorDas, Samarpita
dc.contributor.authorSaha, Pallavi
dc.contributor.authorKoch, Biplob
dc.contributor.authorSharma, Deepak K.
dc.date.accessioned2025-01-28T09:30:26Z
dc.date.available2025-01-28T09:30:26Z
dc.date.issued2023
dc.description.abstractReplacement of electron-donating N,N-dialkyl groups with azacyclic groups has been described as a promising auxochrome to improve the low fluorescent quantum yields (?F) of conventional fluorophores. However, the insufficient brightness and poor solubility of fluorophores pose a significant bottleneck for bioimaging. A new type of fluorescent coumarin dye was designed and synthesized using 7-azaspiroketals as the electron-donating auxochrome group. Such modifications resulted in high-quality coumarin fluorophores with improved solubility and brightness. To the best of our knowledge, this is the first report of using apex-N-substituted azaspiroketals as an electron donor group in any class of donor-acceptor dye. Furthermore, the successful application of these new dyes in biological imaging for living cells has been demonstrated. � 2023 The Royal Society of Chemistry.
dc.identifier.doihttps://doi.org/10.1039/d3nj04934e
dc.identifier.issn11440546
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/21331
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.title7-Azaspiroketal as a unique and effective auxochrome moiety: demonstration in a fluorescent coumarin dye and application in cell imaging
dc.typeArticle
dspace.entity.typePublication
journal.titleNew Journal of Chemistry
journalvolume.identifier.volume47

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2023