Publication:
Synthesis, characterization and antitumor studies of Mn(II), Ni(II), Cu(II) and Zn(II) complexes of N-Nicotinoyl-N′-o-hydroxythiobenzhydrazide

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Date

2003

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Journal Title

BioMetals

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Research Projects

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Abstract

A new ligand N-Nicotinoyl-N′-o-hydroxythiobenzhydrazide (H2Notbh) forms complexes [Mn(Notbh)(H2O)], [M(Notbh)] [M = Ni(II) Cu(II) and Zn(II)] which were characterized by various physico-chemical techniques. All the metal complexes were observed to inhibit the growth of tumor in vitro, whereas, ligand did not. In vivo administration of these complexes resulted in prolongation of survival of tumor bearing mice. Tumor bearing mice administered with metal complexes showed reversal of tumor growth associated induction of apoptosis in lymphocytes. The paper discusses the possible mechanisms and therapeutic implication of the H2Notbh and its metal complexes in tumor regression and tumor growth associated immunosuppression.

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Keywords

3d-metal complexes, Antitumor activity, N-nicotinoyl-N′-o-hydroxythiobenzhydrazide

Citation

URI

https://dl.bhu.ac.in/ir/handle/123456789/88206

DOI

https://doi.org/10.1023/A:1020611428001

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2003