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Polypyridyl CoII-Curcumin Complexes as Photoactivated Anticancer and Antibacterial Agents

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dc.contributor.authorYadav, Ashish Kumar
dc.contributor.authorSingh, Virendra
dc.contributor.authorKushwaha, Rajesh
dc.contributor.authorDolui, Dependu
dc.contributor.authorRai, Rohit
dc.contributor.authorDhar, Prodyut
dc.contributor.authorDutta, Arnab
dc.contributor.authorKoch, Biplob
dc.contributor.authorBanerjee, Samya
dc.date.accessioned2025-01-28T09:46:33Z
dc.date.available2025-01-28T09:46:33Z
dc.date.issued2023
dc.description.abstractFour new CoII complexes, [Co(bpy)2(acac)]Cl (1), [Co(phen)2(acac)]Cl (2), [Co(bpy)2(cur)]Cl (3), [Co(phen)2(cur)]Cl (4), where bpy=2,2�-bipyridine (1 and 3), phen=1,10-phenanthroline (2 and 4), acac=acetylacetonate (1 and 2), cur=curcumin monoanion (3 and 4) have been designed, synthesized and fully characterized. The X-ray crystal structures of 1 and 2 indicated that the CoN4O2 core has a distorted octahedral geometry. The photoactivity of these complexes was tuned by varying the ? conjugation in the ligands. Curcumin complexes 3 and 4 had an intense absorption band near 435 nm, which made them useful as visible-light photodynamic therapy agents; they also showed fluorescence with ?em?565 nm. This fluorescence was useful for studying their intracellular uptake and localization in MCF-7 breast cancer cells. The acetylacetonate complexes (1 and 2) were used as control complexes to understand the role of curcumin. The white-light-triggered anticancer profiles of the cytosol targeting complexes 3 and 4 were investigated in detail. These non-dark toxic complexes displayed significant apoptotic photo-cytotoxicity (under visible light) against MCF-7 cells through ROS generation. The control complexes 1 and 2 did not induce significant cell death in the light or dark. Interestingly, 1-4 produced a remarkable antibacterial response upon light exposure. Overall, the reported results here can increase the boundary of the CoII-based anticancer and antibacterial drug development. � 2023 Wiley-VCH GmbH.
dc.identifier.doihttps://doi.org/10.1002/cbic.202300033
dc.identifier.issn14394227
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/22343
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.subjectanticancer agents
dc.subjectantimicrobial agents
dc.subjectCo<sup>II</sup> complexes
dc.subjectcurcumin-based complexes
dc.subjectphotosensitizers
dc.titlePolypyridyl CoII-Curcumin Complexes as Photoactivated Anticancer and Antibacterial Agents
dc.typeArticle
dspace.entity.typePublication
journal.titleChemBioChem
journalvolume.identifier.volume24

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