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Mechanistic investigations on antifungal and antiaflatoxigenic activities of chemically characterised Carum carvi L. essential oil against fungal infestation and aflatoxin contamination of herbal raw materials

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dc.contributor.authorMaurya, Akash
dc.contributor.authorKumar, Susheel
dc.contributor.authorSingh, Bijendra Kumar
dc.contributor.authorChaudhari, Anand Kumar
dc.contributor.authorDwivedy, Abhishek Kumar
dc.contributor.authorPrakash, Bhanu
dc.contributor.authorDubey, Nawal Kishore
dc.date.accessioned2025-01-27T10:23:54Z
dc.date.available2025-01-27T10:23:54Z
dc.date.issued2022
dc.description.abstractThis study aimed to investigate the efficiency of chemically characterised Carum carvi essential oil (CcEO) against aflatoxin B1 (AFB1) producing strain of Aspergillus flavus (AF-LHP-WS-4) causing deterioration of herbal raw materials (HRM). GC-MS analysis of the EO revealed the presence of carvone (69.85%) as a dominant component. CcEO caused complete suppression of A. flavus growth and AFB1 secretion at 0.7 and 0.6 �L/mL, respectively. The investigation on antifungal mode of action showed that CcEO inhibited fungal growth via abrogating ergosterol biosynthesis and triggered efflux of vital cellular ions. The inhibition of AFB1 biosynthesis was attributed to the inhibition of cellular methylglyoxal (MG) biosynthesis. In addition, CcEO showed remarkable antioxidant activity (IC50 = 10.564 �L/mL) against DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals. Based on overall results, it can be concluded that the CcEO may be recommended as potential antifungal agent for protection of HRM from fungal infestation and AFB1 contamination. � 2021 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.doihttps://doi.org/10.1080/14786419.2021.1994566
dc.identifier.issn14786419
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/15242
dc.publisherTaylor and Francis Ltd.
dc.subjectaflatoxin B<sub>1</sub>
dc.subjectCarum carvi essential oil
dc.subjectherbal raw materials
dc.subjectmethylglyoxal
dc.subjectsafety profile
dc.titleMechanistic investigations on antifungal and antiaflatoxigenic activities of chemically characterised Carum carvi L. essential oil against fungal infestation and aflatoxin contamination of herbal raw materials
dc.typeArticle
dspace.entity.typePublication
journal.titleNatural Product Research
journalvolume.identifier.volume36

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