Publication: Resveratrol as Anti-Obesity and Anticancer Agent
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Date
2021
Journal Title
Obesity and Cancer
Journal ISSN
Volume Title
Publisher
Springer Singapore
Abstract
Resveratrol is a naturally occurring phytochemical, synthesized against various stress responses like infection, UV radiation, and weather change. It plays an important role in the regulation of various biological processes such as inflammation, cell proliferation, apoptosis, calorie restriction, and lipid deposition. Therefore, it exerts several beneficial effects against many diseases such as cancer, cardiovascular diseases, obesity, and diabetes. The anti-obesity potential of resveratrol depends on its ability to regulate adipogenesis, lipogenesis, and lipolysis. The anti-obesity activity of resveratrol also depends on its ability to improve the obesity-altered gut microbiome composition. Moreover, resveratrol exhibits potent anticancer activity against cancer of different origins by inhibiting various cancer-promoting features, including proliferation, apoptosis evasion, invasion, and migration through modulating various signaling pathways. In addition, the adjunct therapeutic potential of resveratrol has also been reported against many cancers. Overall, in this chapter, we have discussed the updated information regarding the anti-obesity and anticancer properties, and adjunct therapeutic potential of resveratrol against obesity and cancer along with associated mechanisms in detail. � The Editor(s) (if applicable) and The Author(s), under exclusive license to Taylor and Francis Pte Ltd. 2021.
Description
Keywords
Adipogenesis, Cancer, Gut microbiota, Lipogenesis, Lipolysis, Resveratrol