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Comparative evaluation of bioglass nanofiber, dexamethasone-coated bioglass nanofiber, and platelet-rich fibrin, as scaffolds in regenerative endodontic treatment of immature necrotic teeth: A randomized controlled trial

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dc.contributor.authorGupta, Sakshi
dc.contributor.authorMittal, Neelam
dc.contributor.authorBaranwal, Harakh Chand
dc.contributor.authorRath, Chandana
dc.contributor.authorShankari, Thivya
dc.contributor.authorGupta, Supriya
dc.date.accessioned2025-01-27T09:50:31Z
dc.date.available2025-01-27T09:50:31Z
dc.date.issued2022
dc.description.abstractAim: The aim of this study was to evaluate and compare the regenerative endodontic potential of dexamethasone-coated bioglass nanofiber (Dex-BGnf), bioglass nanofiber (BGnf), and platelet-rich fibrin (PRF) for inducing regeneration in necrotic immature permanent teeth. Materials and Methods: A total of 36 (n = 12) immature necrotic teeth with or without evidence of periapical lesion were included in the study. Patients were randomly allocated into three groups, based on the scaffolds used: Group I (PRF), II (BGnf), and III (Dex-BGnf). The clinical (electric pulp test) and radiographic evaluations (percentage increase in apical diameter, root length, root dentin thickness, and periapical healing) were compared at 6 and 12 months after the procedure with baseline records. Statistical Analysis: One-way ANOVA, post hoc Tukey analysis, and Kruskal-Wallis test were used for evaluating the data. A 6- and 12-month improvement analysis was done using paired t-test and Friedman test. Results: Clinically, all the 36 teeth were asymptomatic, but none gave a positive response to Electric Pulp Test (EPT) in time interval of 12 months. Dex-BGnf showed a statistically significant improvement in terms of increase in root length (P = 0.020) and root dentinal thickness (P = 0.001) when compared to PRF after 12 months. Conclusion: The study has shown that Dex-BGnf yielded significantly better results than PRF for inducing apexogenesis in necrotic immature teeth. � 2022 Wolters Kluwer Medknow Publications. All rights reserved.
dc.identifier.doihttps://doi.org/10.4103/jcd.jcd-264-22
dc.identifier.issn9720707
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/13157
dc.publisherWolters Kluwer Medknow Publications
dc.subjectBioglass nanofiber
dc.subjectdexamethasone
dc.subjectnanotopography
dc.subjectplatelet-rich fibrin
dc.subjectregeneration
dc.titleComparative evaluation of bioglass nanofiber, dexamethasone-coated bioglass nanofiber, and platelet-rich fibrin, as scaffolds in regenerative endodontic treatment of immature necrotic teeth: A randomized controlled trial
dc.typeArticle
dspace.entity.typePublication
journal.titleJournal of Conservative Dentistry
journalvolume.identifier.volume25

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