Publication:
Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges

Simple item page
dc.contributor.authorSingh, Swarn Lata
dc.contributor.authorChauhan, Keerti
dc.contributor.authorBharadwaj, Atul S.
dc.contributor.authorKishore, Vimal
dc.contributor.authorLaux, Peter
dc.contributor.authorLuch, Andreas
dc.contributor.authorSingh, Ajay Vikram
dc.date.accessioned2025-01-28T09:50:09Z
dc.date.available2025-01-28T09:50:09Z
dc.date.issued2023
dc.description.abstractVarious biological processes involve the translocation of macromolecules across nanopores; these pores are basically protein channels embedded in membranes. Understanding the mechanism of translocation is crucial to a range of technological applications, including DNA sequencing, single molecule detection, and controlled drug delivery. In this spirit, numerous efforts have been made to develop polymer translocation-based sequencing devices, these efforts include findings and insights from theoretical modeling, simulations, and experimental studies. As much as the past and ongoing studies have added to the knowledge, the practical realization of low-cost, high-throughput sequencing devices, however, has still not been realized. There are challenges, the foremost of which is controlling the speed of translocation at the single monomer level, which remain to be addressed in order to use polymer translocation-based methods for sensing applications. In this article, we review the recent studies aimed at developing control over the dynamics of polymer translocation through nanopores. � 2023 by the authors.
dc.identifier.doihttps://doi.org/10.3390/ijms24076153
dc.identifier.issn16616596
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/22560
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.subjectnanopore sequencing
dc.subjectnanopores
dc.subjectpolymer translocation
dc.subjecttranslocation dynamics
dc.titlePolymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges
dc.typeReview
dspace.entity.typePublication
journal.titleInternational Journal of Molecular Sciences
journalvolume.identifier.volume24

Files

Collections

2023