Publication:
Insect-pathogen crosstalk and the cellular-molecular mechanisms of insect immunity: uncovering the underlying signaling pathways and immune regulatory function of non-coding RNAs

Simple item page
dc.contributor.authorMahanta, Deepak Kumar
dc.contributor.authorBhoi, Tanmaya Kumar
dc.contributor.authorKomal, J.
dc.contributor.authorSamal, Ipsita
dc.contributor.authorNikhil, R.M.
dc.contributor.authorPaschapur, Amit Umesh
dc.contributor.authorSingh, Gaurav
dc.contributor.authorKumar, P. V. Dinesh
dc.contributor.authorDesai, H.R.
dc.contributor.authorAhmad, Mohammad Abbas
dc.contributor.authorSingh, P.P.
dc.contributor.authorMajhi, Prasanta Kumar
dc.contributor.authorMukherjee, U.
dc.contributor.authorSingh, Pushpa
dc.contributor.authorSaini, Varun
dc.contributor.authorShahanaz
dc.contributor.authorSrinivasa, N.
dc.contributor.authorYele, Yogesh
dc.date.accessioned2025-01-28T10:03:24Z
dc.date.available2025-01-28T10:03:24Z
dc.date.issued2023
dc.description.abstractMulticellular organisms are constantly subjected to pathogens that might be harmful. Although insects lack an adaptive immune system, they possess highly effective anti-infective mechanisms. Bacterial phagocytosis and parasite encapsulation are some forms of cellular responses. Insects often defend themselves against infections through a humoral response. This phenomenon includes the secretion of antimicrobial peptides into the hemolymph. Specific receptors for detecting infection are required for the recognition of foreign pathogens such as the proteins that recognize glucans and peptidoglycans, together referred to as PGRPs and ?GRPs. Activation of these receptors leads to the stimulation of signaling pathways which further activates the genes encoding for antimicrobial peptides. Some instances of such pathways are the JAK-STAT, Imd, and Toll. The host immune response that frequently accompanies infections has, however, been circumvented by diseases, which may have assisted insects evolve their own complicated immune systems. The role of ncRNAs in insect immunology has been discussed in several notable studies and reviews. This paper examines the most recent research on the immune regulatory function of ncRNAs during insect-pathogen crosstalk, including insect- and pathogen-encoded miRNAs and lncRNAs, and provides an overview of the important insect signaling pathways and effector mechanisms activated by diverse pathogen invaders. Copyright � 2023 Mahanta, Bhoi, Komal, Samal, Nikhil, Paschapur, Singh, Kumar, Desai, Ahmad, Singh, Majhi, Mukherjee, Singh, Saini, Shahanaz, Srinivasa and Yele.
dc.identifier.doihttps://doi.org/10.3389/fimmu.2023.1169152
dc.identifier.issn16643224
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/23382
dc.language.isoen
dc.publisherFrontiers Media SA
dc.subjectantimicrobial peptide
dc.subjecteffector mechanism
dc.subjectimmune system
dc.subjectinsect
dc.subjectinsect-pathogen crosstalk
dc.subjectsignaling pathway
dc.titleInsect-pathogen crosstalk and the cellular-molecular mechanisms of insect immunity: uncovering the underlying signaling pathways and immune regulatory function of non-coding RNAs
dc.typeReview
dspace.entity.typePublication
journal.titleFrontiers in Immunology
journalvolume.identifier.volume14

Files

Collections

2023