Publication:
Pretreatment of mosquito larvae with ultraviolet-B and nitropolycyclic aromatic hydrocarbons induces increased sensitivity to permethrin toxicity

Simple item page
dc.contributor.authorRamkumar, Govindaraju
dc.contributor.authorMuthusamy, Ranganathan
dc.contributor.authorNarayanan, Mathiyazhagan
dc.contributor.authorDhanapal, Rajendran
dc.contributor.authorKarthik, Chinnannan
dc.contributor.authorShivakumar, M.S.
dc.contributor.authorMalathi, Govindhan
dc.contributor.authorKariyanna, B.
dc.date.accessioned2025-01-27T09:47:36Z
dc.date.available2025-01-27T09:47:36Z
dc.date.issued2022
dc.description.abstractNitropolycyclic aromatic hydrocarbons (Nitro-PAH) are highly toxic PHA derivatives. Nitro-PHAs are emitted by carbonaceous materials and PHA post-emission transformation, which causes water and environmental pollution and also exists as carcinogenic and immunotoxic agents. UV light has been shown to cause DNA damage and improves the covalent binding of PAH to DNA significantly. Mosquito breeding grounds are pools of water that can be large open zones or encased ponds with varying levels of sunlight exposure. This research was performed to assess the combined effects of UV-B exposure and Nitro-PAH on the physiological function of Culex quinquefasciatus larvae. To assess the impact of UV-B irradiation and Nitro-PAH exposure on mosquito vectors, parameters were examined: (1) Nitro-PAH availability and its impact on cell fatalities; (2) the detoxifying abilities of cytochrome P450, glutathione-S-transferase, and esterase; (3) the reactions to Reactive Oxygen Species; and (4) The resistance of mosquito larvae to three synthetic pesticides (temephos, imidacloprid, and permethrin). UV-B and Nitro-PAH treatment caused cellular damage and increased major detoxification enzymes such as ? & ?-esterase, cytoP450, CAT, GST, and POX. The levels of oxidative stress, ROS and protein carbonyl content, nitrite, ascorbic acid and thiobarbituric acid were decreased significantly. Toxicology bioassays revealed that UV-B + Nitro-PAH exposure significantly increased larval susceptibility. The current study concludes that prior exposure to Nitro-PAHs and UV-B may make mosquito larvae more vulnerable to chemical insecticides. � 2022 The Authors
dc.identifier.doihttps://doi.org/10.1016/j.heliyon.2022.e11094
dc.identifier.issn24058440
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/13008
dc.publisherElsevier Ltd
dc.subjectControl
dc.subjectCulex quinquefasciatus
dc.subjectDetoxification enzymes
dc.subjectMosquito
dc.subjectNitro-PAH
dc.subjectPermethrin
dc.subjectROS
dc.titlePretreatment of mosquito larvae with ultraviolet-B and nitropolycyclic aromatic hydrocarbons induces increased sensitivity to permethrin toxicity
dc.typeArticle
dspace.entity.typePublication
journal.titleHeliyon
journalvolume.identifier.volume8

Files

Collections

2022