Publication: The role of microRNA-21 in the onset and progression of cancer
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Date
2021
Journal Title
Future Medicinal Chemistry
Journal ISSN
Volume Title
Publisher
Future Medicine Ltd.
Abstract
MicroRNAs (miRNAs), a class of small noncoding RNA, posttranscriptionally regulate the expression of genes. Aberrant expression of miRNA is reported in various types of cancer. Since the first report of oncomiR-21 involvement in the glioma, its upregulation was reported in multiple cancers and was allied with high oncogenic property. In addition to the downregulation of tumor suppressor genes, the miR-21 is also associated with cancer resistance to various chemotherapy. The recent research is appraising miR-21 as a promising cancer target and biomarker for early cancer detection. In this review, we briefly explain the biogenesis and regulation of miR-21 in cancer cells. Additionally, the review features the assorted genes/pathways regulated by the miR-21 in various cancer and cancer stem cells. � 2021 Newlands Press.
Description
Keywords
Apoptosis, Cancer, Cancer stem cells, Carcinogenesis, Metastasis, miR-21, miRNA