Publication:
Influence of adjuvant therapy on pattern of failure and survival in curatively resected gallbladder carcinoma

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dc.contributor.authorChoudhary, Sunil
dc.contributor.authorGupta, Neha
dc.contributor.authorVerma, Chandra Prakash
dc.contributor.authorDas, Avipsa
dc.contributor.authorAggarwal, Lalit Mohan
dc.contributor.authorTewari, Mallika
dc.contributor.authorMandal, Abhijit
dc.contributor.authorAsthana, Anupam Kumar
dc.date.accessioned2025-01-30T06:00:19Z
dc.date.available2025-01-30T06:00:19Z
dc.date.issued2021
dc.description.abstractPurpose: The study was done to evaluate the role of adjuvant therapy in curatively resected Stage II and III gallbladder carcinoma (GBC). Materials and Methods: This was a retrospective analysis of patients of GBC registered between 2008 and 2017 in outpatient department of a tertiary cancer hospital in India. Patients who had any of the following adjuvant treatment after radical surgery: (a) external beam radiotherapy (RT) alone, (b) chemotherapy (CT) alone, and (c) RT with CT (CRT) were considered for the study. Results: A total of fifty patients could meet the selection criteria. It was seen that seven patients were treated with RT, 20 with CT, and 23 with CRT. Median follow-up for patients who were alive was 26.7 months. Nineteen patients had locoregional failure while eight had distant failure. Patients treated with CRT had a significantly better mean overall survival compared to those treated with RT or CT (44.0 months, 12.5 months, and 15.1 months, respectively; P = 0.003). Similarly, mean disease-free survival was superior in CRT arm compared to RT and CT arms (43.6 months, 9.6 months, and 12.4 months, respectively; P = 0.002). Conclusions: Adjuvant CRT had better survival outcome compared to patients treated with either RT or CT with Stage II and III disease after curative cholecystectomy. � 2020 Journal of Cancer Research and Therapeutics.
dc.identifier.doihttps://doi.org/10.4103/jcrt.JCRT_550_19
dc.identifier.issn9731482
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/24852
dc.publisherWolters Kluwer Medknow Publications
dc.subjectAdjuvant chemotherapy
dc.subjectAdjuvant radiotherapy
dc.subjectCholecystectomy
dc.subjectCombined modality therapy
dc.subjectGallbladder cancer
dc.titleInfluence of adjuvant therapy on pattern of failure and survival in curatively resected gallbladder carcinoma
dc.typeArticle
dspace.entity.typePublication
journal.titleJournal of Cancer Research and Therapeutics
journalvolume.identifier.volume17

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2021