Publication:
Contemporary approaches in the management of uterine leiomyomas

Simple item page
dc.contributor.authorSingh, Shikha
dc.contributor.authorKumar, Praveen
dc.contributor.authorKavita
dc.contributor.authorRathore, Saurabh Singh
dc.contributor.authorSingh, Yashasvi
dc.contributor.authorGarg, Neha
dc.date.accessioned2025-01-28T09:40:47Z
dc.date.available2025-01-28T09:40:47Z
dc.date.issued2023
dc.description.abstractBackground: Leiomyomas (fibroids), the most common benign solid tumours in females, originate from the myometrium and are associated with poor quality of life for patients. The current management of uterine leiomyomas mainly includes surgical interventions such as hysterectomy and myomectomy, either by laparoscopy or laparotomy, which have several complications and are not ideal for preserving fertility. Therefore, there is a need to develop or repurpose medical treatments that do not require surgical intervention. Objective: Many drugs are used to treat the symptoms associated with uterine fibroids. The main objective of this systematic review is to give an up-to-date account of potential pharmacological agents (non-surgical methods) for the management of uterine leiomyomas. Search strategy: PubMed was searched for scientific and clinical literature using the keyword �uterine fibroids� along with the drug names described in each section. For example, �uterine fibroids� and �ulipristal acetate� were the keywords used to search for literature on ulipristal acetate (UPA). Results: Various preclinical and clinical studies have shown that some drugs and herbal formulations exhibit activity in the management of uterine leiomyomas. Recent studies found that drugs such as UPA, elagolix, EC313, asoprisnol, nutritional supplements and herbal preparations were helpful in treating the symptoms associated with uterine leiomyomas. Conclusion: Many drugs show efficacy in patients with symptomatic uterine fibroids. UPA is one of the most studied and prescribed medicines for uterine fibroids; however, its usage has been restricted due to a few recent incidences of hepatic toxicity. Herbal drugs and natural supplements have also shown promising effects on uterine fibroids. The synergistic effects of nutritional and herbal supplements have been reported in certain cases, and should be studied in detail. Further research is warranted to identify the mode of action of the drugs, and to determine the precise conditions that would explain the causes of toxicity in some patients. � 2023 Elsevier B.V.
dc.identifier.doihttps://doi.org/10.1016/j.ejogrb.2023.06.021
dc.identifier.issn3012115
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/21993
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.subjectCOMTI
dc.subjectFIGO
dc.subjectGnRH antagonists
dc.subjectHerbs
dc.subjectLeiomyoma
dc.subjectMedical management
dc.subjectUPA
dc.subjectUterine fibroids
dc.titleContemporary approaches in the management of uterine leiomyomas
dc.typeReview
dspace.entity.typePublication
journal.titleEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
journalvolume.identifier.volume287

Files

Collections

2023