Publication: Isolation of a new cytotoxic colchinoid from Gloriosa superba roots
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Date
2023
Journal Title
Natural Product Research
Journal ISSN
Volume Title
Publisher
Taylor and Francis Ltd.
Abstract
A new colchinoid compound, identified as N-deacetyl-N-formylcornigerine (1), named glorigerine was isolated from the roots of Gloriosa superba, along with two known compounds. The structures of isolated compounds were elucidated by 1 D and 2 D NMR and HRMS experiments. Glorigerine (1) differed from cornigerine (6) by the presence of an N-formyl group instead of the N-acetyl group. Glorigerine (1) was found to have moderate cytotoxicity when tested against four human cancer cell lines. � 2022 Informa UK Limited, trading as Taylor & Francis Group.
Description
Keywords
colchinoid, cytotoxicity, glorigerine, Gloriosa superba, natural product