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Biological potential of bioactive metabolites derived from fungal endophytes associated with medicinal plants

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dc.contributor.authorKeshri, Priyanka Kumari
dc.contributor.authorRai, Nilesh
dc.contributor.authorVerma, Ashish
dc.contributor.authorKamble, Swapnil C.
dc.contributor.authorBarik, Suvakanta
dc.contributor.authorMishra, Pradeep
dc.contributor.authorSingh, Santosh Kumar
dc.contributor.authorSalvi, Prafull
dc.contributor.authorGautam, Vibhav
dc.date.accessioned2025-01-30T06:03:40Z
dc.date.available2025-01-30T06:03:40Z
dc.date.issued2021
dc.description.abstractEndophytes are endosymbiotic fungi or bacteria that invade and colonize the plant tissue without harming their respective host. Since fungal endophytes live inside the host tissues, their effective isolation and identification is an important step. Endophytic fungi produce bioactive metabolites with unique chemical structures, which may help in improving the physiological condition of both the plants and endophytes. Endophytic fungi are a potent source of all major classes of secondary metabolites including terpenoids, non-ribosomal peptides, polyketides, and alkaloids. With the increase in the number of diseases and human health problems, an intensive search for new sources and effective metabolites is now in progress. The bioactive metabolites produced by the fungal endophytes are competent and effective against various diseases such as cancer, diabetes, infectious diseases, immunological disorders, and cardiovascular diseases. The present review summarizes the efficient approaches used for the screening of fungal endophytes, extraction, and purification of bioactive metabolites along with OMICS based study of endophytes. Along with this, the pharmaceutical importance of novel bioactive metabolites and their efficient production from fungal endophytes using various approaches like genetic engineering, use of elicitors, and precursor feeding are also discussed. � 2021, German Mycological Society and Springer-Verlag GmbH Germany, part of Springer Nature.
dc.identifier.doihttps://doi.org/10.1007/s11557-021-01695-8
dc.identifier.issn1617416X
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/25125
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.subjectFungal endophyte
dc.subjectGenomics
dc.subjectSecondary metabolite
dc.subjectTranscriptomics
dc.titleBiological potential of bioactive metabolites derived from fungal endophytes associated with medicinal plants
dc.typeReview
dspace.entity.typePublication
journal.titleMycological Progress
journalvolume.identifier.volume20

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2021